Should we do early and frequent charcoal hemoperfusion in phenytoin toxicity?

Phenytoin toxicity or adverse drug reaction is common due to its narrow therapeutic window. Mild and moderate toxicity require supportive care and enteral activated charcoal. In severe toxicity, charcoal hemoperfusion (CHP) have been shown to decrease serum phenytoin half-life and early recovery. He...

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Detalles Bibliográficos
Autores principales: Sahoo, Jyoti Narayan, Gurjar, Mohan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810927/
https://www.ncbi.nlm.nih.gov/pubmed/27076716
http://dx.doi.org/10.4103/0972-5229.175936
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author Sahoo, Jyoti Narayan
Gurjar, Mohan
author_facet Sahoo, Jyoti Narayan
Gurjar, Mohan
author_sort Sahoo, Jyoti Narayan
collection PubMed
description Phenytoin toxicity or adverse drug reaction is common due to its narrow therapeutic window. Mild and moderate toxicity require supportive care and enteral activated charcoal. In severe toxicity, charcoal hemoperfusion (CHP) have been shown to decrease serum phenytoin half-life and early recovery. Here, we report two cases with phenytoin toxicity who showed marked clinical improvement after early and frequent CHP treatment.
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spelling pubmed-48109272016-04-13 Should we do early and frequent charcoal hemoperfusion in phenytoin toxicity? Sahoo, Jyoti Narayan Gurjar, Mohan Indian J Crit Care Med Case Report Phenytoin toxicity or adverse drug reaction is common due to its narrow therapeutic window. Mild and moderate toxicity require supportive care and enteral activated charcoal. In severe toxicity, charcoal hemoperfusion (CHP) have been shown to decrease serum phenytoin half-life and early recovery. Here, we report two cases with phenytoin toxicity who showed marked clinical improvement after early and frequent CHP treatment. Medknow Publications & Media Pvt Ltd 2016-02 /pmc/articles/PMC4810927/ /pubmed/27076716 http://dx.doi.org/10.4103/0972-5229.175936 Text en Copyright: © Indian Journal of Critical Care Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Sahoo, Jyoti Narayan
Gurjar, Mohan
Should we do early and frequent charcoal hemoperfusion in phenytoin toxicity?
title Should we do early and frequent charcoal hemoperfusion in phenytoin toxicity?
title_full Should we do early and frequent charcoal hemoperfusion in phenytoin toxicity?
title_fullStr Should we do early and frequent charcoal hemoperfusion in phenytoin toxicity?
title_full_unstemmed Should we do early and frequent charcoal hemoperfusion in phenytoin toxicity?
title_short Should we do early and frequent charcoal hemoperfusion in phenytoin toxicity?
title_sort should we do early and frequent charcoal hemoperfusion in phenytoin toxicity?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810927/
https://www.ncbi.nlm.nih.gov/pubmed/27076716
http://dx.doi.org/10.4103/0972-5229.175936
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