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Large-Scale Functional RNAi Screen in C. elegans Identifies TGF-β and Notch Signaling Pathways as Modifiers of CACNA1A

Variants in CACNA1A that encodes the pore-forming α(1)-subunit of human voltage-gated Cav2.1 (P/Q-type) Ca(2+) channels cause several autosomal-dominant neurologic disorders, including familial hemiplegic migraine type 1, episodic ataxia type 2, and spinocerebellar ataxia type 6. To identify modifie...

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Detalles Bibliográficos
Autores principales:	Pereira, Maria da Conceição, Morais, Sara, Sequeiros, Jorge, Alonso, Isabel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811018/ https://www.ncbi.nlm.nih.gov/pubmed/27005779 http://dx.doi.org/10.1177/1759091416637025

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