Cargando…
Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels
Vitamin D levels of pregnant women and their neonates tend to be related; however, it is unknown whether there are any subgroups in which they are not related. 25-Hydroxyvitamin D [25(OH)D] was measured in prenatal maternal and child cord blood samples of participants (n = 241 pairs) in a birth coho...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811107/ https://www.ncbi.nlm.nih.gov/pubmed/27066272 http://dx.doi.org/10.1155/2016/7474192 |
_version_ | 1782423904658128896 |
---|---|
author | Wegienka, Ganesa Kaur, Hareena Sangha, Roopina Cassidy-Bushrow, Andrea E. |
author_facet | Wegienka, Ganesa Kaur, Hareena Sangha, Roopina Cassidy-Bushrow, Andrea E. |
author_sort | Wegienka, Ganesa |
collection | PubMed |
description | Vitamin D levels of pregnant women and their neonates tend to be related; however, it is unknown whether there are any subgroups in which they are not related. 25-Hydroxyvitamin D [25(OH)D] was measured in prenatal maternal and child cord blood samples of participants (n = 241 pairs) in a birth cohort. Spearman correlations were examined within subgroups defined by prenatal and delivery factors. Cord blood as a percentage of prenatal 25(OH)D level was calculated and characteristics compared between those who did and did not have ≥25% and ≥50% of the maternal level and those who did and did not have a detectable 25(OH)D level. The correlation among Black children was lower than in White children. When the maternal 25(OH)D level was <15 ng/mL, the overall correlation was r = 0.16. Most children had a 25(OH)D cord blood level less than half of their mother's; 15.4% had a level that was <25% of their mother's. Winter birth and maternal level were associated with the level being less than 25%. Children with undetectable levels were more likely to be Black and less likely to be firstborn. These data suggest mothers may reduce their contribution to the fetus's 25(OH)D supply once their own level becomes low. |
format | Online Article Text |
id | pubmed-4811107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48111072016-04-10 Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels Wegienka, Ganesa Kaur, Hareena Sangha, Roopina Cassidy-Bushrow, Andrea E. J Pregnancy Research Article Vitamin D levels of pregnant women and their neonates tend to be related; however, it is unknown whether there are any subgroups in which they are not related. 25-Hydroxyvitamin D [25(OH)D] was measured in prenatal maternal and child cord blood samples of participants (n = 241 pairs) in a birth cohort. Spearman correlations were examined within subgroups defined by prenatal and delivery factors. Cord blood as a percentage of prenatal 25(OH)D level was calculated and characteristics compared between those who did and did not have ≥25% and ≥50% of the maternal level and those who did and did not have a detectable 25(OH)D level. The correlation among Black children was lower than in White children. When the maternal 25(OH)D level was <15 ng/mL, the overall correlation was r = 0.16. Most children had a 25(OH)D cord blood level less than half of their mother's; 15.4% had a level that was <25% of their mother's. Winter birth and maternal level were associated with the level being less than 25%. Children with undetectable levels were more likely to be Black and less likely to be firstborn. These data suggest mothers may reduce their contribution to the fetus's 25(OH)D supply once their own level becomes low. Hindawi Publishing Corporation 2016 2016-03-15 /pmc/articles/PMC4811107/ /pubmed/27066272 http://dx.doi.org/10.1155/2016/7474192 Text en Copyright © 2016 Ganesa Wegienka et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wegienka, Ganesa Kaur, Hareena Sangha, Roopina Cassidy-Bushrow, Andrea E. Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels |
title | Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels |
title_full | Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels |
title_fullStr | Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels |
title_full_unstemmed | Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels |
title_short | Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels |
title_sort | maternal-cord blood vitamin d correlations vary by maternal levels |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811107/ https://www.ncbi.nlm.nih.gov/pubmed/27066272 http://dx.doi.org/10.1155/2016/7474192 |
work_keys_str_mv | AT wegienkaganesa maternalcordbloodvitamindcorrelationsvarybymaternallevels AT kaurhareena maternalcordbloodvitamindcorrelationsvarybymaternallevels AT sangharoopina maternalcordbloodvitamindcorrelationsvarybymaternallevels AT cassidybushrowandreae maternalcordbloodvitamindcorrelationsvarybymaternallevels |