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Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels

Vitamin D levels of pregnant women and their neonates tend to be related; however, it is unknown whether there are any subgroups in which they are not related. 25-Hydroxyvitamin D [25(OH)D] was measured in prenatal maternal and child cord blood samples of participants (n = 241 pairs) in a birth coho...

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Autores principales: Wegienka, Ganesa, Kaur, Hareena, Sangha, Roopina, Cassidy-Bushrow, Andrea E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811107/
https://www.ncbi.nlm.nih.gov/pubmed/27066272
http://dx.doi.org/10.1155/2016/7474192
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author Wegienka, Ganesa
Kaur, Hareena
Sangha, Roopina
Cassidy-Bushrow, Andrea E.
author_facet Wegienka, Ganesa
Kaur, Hareena
Sangha, Roopina
Cassidy-Bushrow, Andrea E.
author_sort Wegienka, Ganesa
collection PubMed
description Vitamin D levels of pregnant women and their neonates tend to be related; however, it is unknown whether there are any subgroups in which they are not related. 25-Hydroxyvitamin D [25(OH)D] was measured in prenatal maternal and child cord blood samples of participants (n = 241 pairs) in a birth cohort. Spearman correlations were examined within subgroups defined by prenatal and delivery factors. Cord blood as a percentage of prenatal 25(OH)D level was calculated and characteristics compared between those who did and did not have ≥25% and ≥50% of the maternal level and those who did and did not have a detectable 25(OH)D level. The correlation among Black children was lower than in White children. When the maternal 25(OH)D level was <15 ng/mL, the overall correlation was r = 0.16. Most children had a 25(OH)D cord blood level less than half of their mother's; 15.4% had a level that was <25% of their mother's. Winter birth and maternal level were associated with the level being less than 25%. Children with undetectable levels were more likely to be Black and less likely to be firstborn. These data suggest mothers may reduce their contribution to the fetus's 25(OH)D supply once their own level becomes low.
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spelling pubmed-48111072016-04-10 Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels Wegienka, Ganesa Kaur, Hareena Sangha, Roopina Cassidy-Bushrow, Andrea E. J Pregnancy Research Article Vitamin D levels of pregnant women and their neonates tend to be related; however, it is unknown whether there are any subgroups in which they are not related. 25-Hydroxyvitamin D [25(OH)D] was measured in prenatal maternal and child cord blood samples of participants (n = 241 pairs) in a birth cohort. Spearman correlations were examined within subgroups defined by prenatal and delivery factors. Cord blood as a percentage of prenatal 25(OH)D level was calculated and characteristics compared between those who did and did not have ≥25% and ≥50% of the maternal level and those who did and did not have a detectable 25(OH)D level. The correlation among Black children was lower than in White children. When the maternal 25(OH)D level was <15 ng/mL, the overall correlation was r = 0.16. Most children had a 25(OH)D cord blood level less than half of their mother's; 15.4% had a level that was <25% of their mother's. Winter birth and maternal level were associated with the level being less than 25%. Children with undetectable levels were more likely to be Black and less likely to be firstborn. These data suggest mothers may reduce their contribution to the fetus's 25(OH)D supply once their own level becomes low. Hindawi Publishing Corporation 2016 2016-03-15 /pmc/articles/PMC4811107/ /pubmed/27066272 http://dx.doi.org/10.1155/2016/7474192 Text en Copyright © 2016 Ganesa Wegienka et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wegienka, Ganesa
Kaur, Hareena
Sangha, Roopina
Cassidy-Bushrow, Andrea E.
Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels
title Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels
title_full Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels
title_fullStr Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels
title_full_unstemmed Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels
title_short Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels
title_sort maternal-cord blood vitamin d correlations vary by maternal levels
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811107/
https://www.ncbi.nlm.nih.gov/pubmed/27066272
http://dx.doi.org/10.1155/2016/7474192
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