The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction

PURPOSE: To investigate the expression of humanin (HN) in human retinal pigment epithelial (hRPE) cells and its effect on oxidative stress–induced cell death, mitochondrial bioenergetics, and senescence. METHODS: Humanin localization in RPE cells and polarized RPE monolayers was assessed by confocal...

Descripción completa

Detalles Bibliográficos
Autores principales: Sreekumar, Parameswaran G., Ishikawa, Keijiro, Spee, Chris, Mehta, Hemal H., Wan, Junxiang, Yen, Kelvin, Cohen, Pinchas, Kannan, Ram, Hinton, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2016
Materias:
Retinal Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811181/
https://www.ncbi.nlm.nih.gov/pubmed/26990160
http://dx.doi.org/10.1167/iovs.15-17053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811181/
https://www.ncbi.nlm.nih.gov/pubmed/26990160
http://dx.doi.org/10.1167/iovs.15-17053

Ejemplares similares