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The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction

PURPOSE: To investigate the expression of humanin (HN) in human retinal pigment epithelial (hRPE) cells and its effect on oxidative stress–induced cell death, mitochondrial bioenergetics, and senescence. METHODS: Humanin localization in RPE cells and polarized RPE monolayers was assessed by confocal...

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Detalles Bibliográficos
Autores principales:	Sreekumar, Parameswaran G., Ishikawa, Keijiro, Spee, Chris, Mehta, Hemal H., Wan, Junxiang, Yen, Kelvin, Cohen, Pinchas, Kannan, Ram, Hinton, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2016
Materias:	Retinal Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811181/ https://www.ncbi.nlm.nih.gov/pubmed/26990160 http://dx.doi.org/10.1167/iovs.15-17053

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