The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction

PURPOSE: The translational repressor 4E-BP1 interacts with the mRNA cap-binding protein eIF4E and thereby promotes cap-independent translation of mRNAs encoding proteins that contribute to diabetic retinopathy. Interaction of 4E-BP1 with eIF4E is enhanced in the retina of diabetic rodents, at least...

Descripción completa

Detalles Bibliográficos
Autores principales: Miller, William P., Mihailescu, Maria L., Yang, Chen, Barber, Alistair J., Kimball, Scot R., Jefferson, Leonard S., Dennis, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2016
Materias:
Biochemistry and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811182/
https://www.ncbi.nlm.nih.gov/pubmed/26998719
http://dx.doi.org/10.1167/iovs.15-18719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811182/
https://www.ncbi.nlm.nih.gov/pubmed/26998719
http://dx.doi.org/10.1167/iovs.15-18719

Ejemplares similares