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The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction

PURPOSE: The translational repressor 4E-BP1 interacts with the mRNA cap-binding protein eIF4E and thereby promotes cap-independent translation of mRNAs encoding proteins that contribute to diabetic retinopathy. Interaction of 4E-BP1 with eIF4E is enhanced in the retina of diabetic rodents, at least...

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Detalles Bibliográficos
Autores principales:	Miller, William P., Mihailescu, Maria L., Yang, Chen, Barber, Alistair J., Kimball, Scot R., Jefferson, Leonard S., Dennis, Michael D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2016
Materias:	Biochemistry and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811182/ https://www.ncbi.nlm.nih.gov/pubmed/26998719 http://dx.doi.org/10.1167/iovs.15-18719

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