Cell-Based Therapy for Silicosis

Silicosis is the most common pneumoconiosis globally, with higher prevalence and incidence in developing countries. To date, there is no effective treatment to halt or reverse the disease progression caused by silica-induced lung injury. Significant advances have to be made in order to reduce morbid...

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Detalles Bibliográficos
Autores principales: Lopes-Pacheco, Miquéias, Bandeira, Elga, Morales, Marcelo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811211/
https://www.ncbi.nlm.nih.gov/pubmed/27066079
http://dx.doi.org/10.1155/2016/5091838
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author Lopes-Pacheco, Miquéias
Bandeira, Elga
Morales, Marcelo M.
author_facet Lopes-Pacheco, Miquéias
Bandeira, Elga
Morales, Marcelo M.
author_sort Lopes-Pacheco, Miquéias
collection PubMed
description Silicosis is the most common pneumoconiosis globally, with higher prevalence and incidence in developing countries. To date, there is no effective treatment to halt or reverse the disease progression caused by silica-induced lung injury. Significant advances have to be made in order to reduce morbidity and mortality related to silicosis. In this review, we have highlighted the main mechanisms of action that cause lung damage by silica particles and summarized the data concerning the therapeutic promise of cell-based therapy for silicosis.
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spelling pubmed-48112112016-04-10 Cell-Based Therapy for Silicosis Lopes-Pacheco, Miquéias Bandeira, Elga Morales, Marcelo M. Stem Cells Int Review Article Silicosis is the most common pneumoconiosis globally, with higher prevalence and incidence in developing countries. To date, there is no effective treatment to halt or reverse the disease progression caused by silica-induced lung injury. Significant advances have to be made in order to reduce morbidity and mortality related to silicosis. In this review, we have highlighted the main mechanisms of action that cause lung damage by silica particles and summarized the data concerning the therapeutic promise of cell-based therapy for silicosis. Hindawi Publishing Corporation 2016 2016-03-15 /pmc/articles/PMC4811211/ /pubmed/27066079 http://dx.doi.org/10.1155/2016/5091838 Text en Copyright © 2016 Miquéias Lopes-Pacheco et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lopes-Pacheco, Miquéias
Bandeira, Elga
Morales, Marcelo M.
Cell-Based Therapy for Silicosis
title Cell-Based Therapy for Silicosis
title_full Cell-Based Therapy for Silicosis
title_fullStr Cell-Based Therapy for Silicosis
title_full_unstemmed Cell-Based Therapy for Silicosis
title_short Cell-Based Therapy for Silicosis
title_sort cell-based therapy for silicosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811211/
https://www.ncbi.nlm.nih.gov/pubmed/27066079
http://dx.doi.org/10.1155/2016/5091838
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