Allicin Induces Calcium and Mitochondrial Dysregulation Causing Necrotic Death in Leishmania

BACKGROUND: Allicin has shown antileishmanial activity in vitro and in vivo. However the mechanism of action underlying its antiproliferative effect against Leishmania has been virtually unexplored. In this paper, we present the results obtained in L.infantum and a mechanistic basis is proposed. MET...

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Detalles Bibliográficos
Autores principales: Corral, María J., Benito-Peña, Elena, Jiménez-Antón, M. Dolores, Cuevas, Laureano, Moreno-Bondi, María C., Alunda, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811430/
https://www.ncbi.nlm.nih.gov/pubmed/27023069
http://dx.doi.org/10.1371/journal.pntd.0004525

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