Cargando…
Can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis?
OBJECTIVES: This review stated the possible application of the active components of licorice, glycyrrhizin (GL) and glycyrrhetinic acid (GA), in rheumatoid arthritis (RA) treatment based on the cyclooxygenase (COX)-2/thromboxane A2 (TxA2) pathway. METHODS: The extensive literature from inception to...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811453/ https://www.ncbi.nlm.nih.gov/pubmed/26498361 |
_version_ | 1782423961823346688 |
---|---|
author | Huang, Qing-Chun Wang, Mao-Jie Chen, Xiu-Min Yu, Wan-Lin Chu, Yong-Liang He, Xiao-Hong Huang, Run-Yue |
author_facet | Huang, Qing-Chun Wang, Mao-Jie Chen, Xiu-Min Yu, Wan-Lin Chu, Yong-Liang He, Xiao-Hong Huang, Run-Yue |
author_sort | Huang, Qing-Chun |
collection | PubMed |
description | OBJECTIVES: This review stated the possible application of the active components of licorice, glycyrrhizin (GL) and glycyrrhetinic acid (GA), in rheumatoid arthritis (RA) treatment based on the cyclooxygenase (COX)-2/thromboxane A2 (TxA2) pathway. METHODS: The extensive literature from inception to July 2015 was searched in PubMed central, and relevant reports were identified according to the purpose of this study. RESULTS: The active components of licorice GL and GA exert the potential anti-inflammatory effects through, at least in part, suppressing COX-2 and its downstream product TxA2. Additionally, the COX-2/TxA2 pathway, an auto-regulatory feedback loop, has been recently found to be a crucial mechanism underlying the pathogenesis of RA. However, TxA2 is neither the pharmacological target of non-steroidal anti-inflammatory drugs (NSAIDs) nor the target of disease modifying anti-rheumatic drugs (DMARDs), and the limitations and side effects of those drugs may be, at least in part, attributable to lack of the effects on the COX-2/TxA2 pathway. Therefore, GL and GA capable of targeting this pathway hold the potential as a novel add-on therapy in therapeutic strategy, which is supported by several bench experiments. CONCLUSIONS: The active components of licorice, GL and GA, could not only potentiate the therapeutic effects but also decrease the adverse effects of NSAIDs or DMARDs through suppressing the COX-2/TxA2 pathway during treatment course of RA. |
format | Online Article Text |
id | pubmed-4811453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-48114532016-04-25 Can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis? Huang, Qing-Chun Wang, Mao-Jie Chen, Xiu-Min Yu, Wan-Lin Chu, Yong-Liang He, Xiao-Hong Huang, Run-Yue Oncotarget Review OBJECTIVES: This review stated the possible application of the active components of licorice, glycyrrhizin (GL) and glycyrrhetinic acid (GA), in rheumatoid arthritis (RA) treatment based on the cyclooxygenase (COX)-2/thromboxane A2 (TxA2) pathway. METHODS: The extensive literature from inception to July 2015 was searched in PubMed central, and relevant reports were identified according to the purpose of this study. RESULTS: The active components of licorice GL and GA exert the potential anti-inflammatory effects through, at least in part, suppressing COX-2 and its downstream product TxA2. Additionally, the COX-2/TxA2 pathway, an auto-regulatory feedback loop, has been recently found to be a crucial mechanism underlying the pathogenesis of RA. However, TxA2 is neither the pharmacological target of non-steroidal anti-inflammatory drugs (NSAIDs) nor the target of disease modifying anti-rheumatic drugs (DMARDs), and the limitations and side effects of those drugs may be, at least in part, attributable to lack of the effects on the COX-2/TxA2 pathway. Therefore, GL and GA capable of targeting this pathway hold the potential as a novel add-on therapy in therapeutic strategy, which is supported by several bench experiments. CONCLUSIONS: The active components of licorice, GL and GA, could not only potentiate the therapeutic effects but also decrease the adverse effects of NSAIDs or DMARDs through suppressing the COX-2/TxA2 pathway during treatment course of RA. Impact Journals LLC 2015-10-20 /pmc/articles/PMC4811453/ /pubmed/26498361 Text en Copyright: © 2016 Huang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Huang, Qing-Chun Wang, Mao-Jie Chen, Xiu-Min Yu, Wan-Lin Chu, Yong-Liang He, Xiao-Hong Huang, Run-Yue Can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis? |
title | Can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis? |
title_full | Can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis? |
title_fullStr | Can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis? |
title_full_unstemmed | Can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis? |
title_short | Can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis? |
title_sort | can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811453/ https://www.ncbi.nlm.nih.gov/pubmed/26498361 |
work_keys_str_mv | AT huangqingchun canactivecomponentsoflicoriceglycyrrhizinandglycyrrhetinicacidlickrheumatoidarthritis AT wangmaojie canactivecomponentsoflicoriceglycyrrhizinandglycyrrhetinicacidlickrheumatoidarthritis AT chenxiumin canactivecomponentsoflicoriceglycyrrhizinandglycyrrhetinicacidlickrheumatoidarthritis AT yuwanlin canactivecomponentsoflicoriceglycyrrhizinandglycyrrhetinicacidlickrheumatoidarthritis AT chuyongliang canactivecomponentsoflicoriceglycyrrhizinandglycyrrhetinicacidlickrheumatoidarthritis AT hexiaohong canactivecomponentsoflicoriceglycyrrhizinandglycyrrhetinicacidlickrheumatoidarthritis AT huangrunyue canactivecomponentsoflicoriceglycyrrhizinandglycyrrhetinicacidlickrheumatoidarthritis |