Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma

Melanoma is the most aggressive and deadly form of cutaneous neoplasm due to its propensity to metastasize. Oncogenic BRAF drives sustained activation of the BRAF/MEK/ERK (MAPK) pathway and cooperates with PI3K/AKT/mTOR (PI3K) signaling to induce epithelial to mesenchymal transition (EMT), leading t...

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Detalles Bibliográficos
Autores principales: Pal, Harish C., Diamond, Ariana C., Strickland, Leah R., Kappes, John C., Katiyar, Santosh K., Elmets, Craig A., Athar, Mohammad, Afaq, Farrukh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811456/
https://www.ncbi.nlm.nih.gov/pubmed/26517521

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