Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy

This study identifies BNIP3L as the key regulator of p53-dependent cell death mechanism in colon cancer cells targeted by the novel gallium based anticancer drug, KP46. KP46 specifically accumulated into mitochondria where it caused p53-dependent morphological and functional damage impairing mitocho...

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Detalles Bibliográficos
Autores principales: Wilfinger, Nastasia, Austin, Shane, Scheiber-Mojdehkar, Barbara, Berger, Walter, Reipert, Siegfried, Praschberger, Monika, Paur, Jakob, Trondl, Robert, Keppler, Bernhard K., Zielinski, Christoph C., Nowikovsky, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811457/
https://www.ncbi.nlm.nih.gov/pubmed/26517689

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