KIT over-expression by p55PIK-PI3K leads to Imatinib-resistance in patients with gastrointestinal stromal tumors

Imatinib is the first-line drug for gastrointestinal stromal tumors (GISTs), as mutated KIT is closely associated with the occurrence of GIST. However, Imatinib resistance (IMA-resistance) occurs inevitably in most GIST patients. Although the over-expression of KIT in GIST is one of the major factor...

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Detalles Bibliográficos
Autores principales: Lai, Senyan, Wang, Guihua, Cao, Xiaonian, Luo, Xuelai, Wang, Guoping, Xia, Xianmin, Hu, Junbo, Wang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811466/
https://www.ncbi.nlm.nih.gov/pubmed/26587973

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