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Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth

Pyruvate dehydrogenase kinase-1 (PDK1), a key metabolic enzyme involved in aerobic glycolysis, is highly expressed in many solid tumors. Small molecule compound DAP (2,2-dichloroacetophenone) is a potent inhibitor of PDK1. Whether targeting PDK1 with DAP can inhibit acute myeloid leukemia (AML) and...

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Detalles Bibliográficos
Autores principales:	Qin, Lijun, Tian, Yun, Yu, Zhenlong, Shi, Dingbo, Wang, Jingshu, Zhang, Changlin, Peng, Ruoyu, Chen, Xuezhen, Liu, Congcong, Chen, Yiming, Huang, Wenlin, Deng, Wuguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811468/ https://www.ncbi.nlm.nih.gov/pubmed/26593251

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