Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma

Ewing sarcomas (ES) are highly malignant bone or soft tissue tumors. Genetically, ES are defined by balanced chromosomal EWS/ETS translocations, which give rise to chimeric proteins (EWS-ETS) that generate an oncogenic transcriptional program associated with altered epigenetic marks throughout the g...

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Detalles Bibliográficos
Autores principales: Hensel, Tim, Giorgi, Chiara, Schmidt, Oxana, Calzada-Wack, Julia, Neff, Frauke, Buch, Thorsten, Niggli, Felix K., Schäfer, Beat W., Burdach, Stefan, Richter, Günther H.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811472/
https://www.ncbi.nlm.nih.gov/pubmed/26623725

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