Critical role of PPARγ in myeloid-derived suppressor cell-stimulated cancer cell proliferation and metastasis

Lysosomal acid lipase (LAL) is a key enzyme controlling neutral lipid metabolic signaling in myeloid-derived suppressor cells (MDSCs). MDSCs from LAL-deficient (lal(−/−)) mice directly stimulate cancer cell proliferation. PPARγ ligand treatment inhibited lal(−/−) MDSCs stimulation of tumor cell grow...

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Detalles Bibliográficos
Autores principales: Zhao, Ting, Du, Hong, Blum, Janice S., Yan, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811478/
https://www.ncbi.nlm.nih.gov/pubmed/26625314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811478/
https://www.ncbi.nlm.nih.gov/pubmed/26625314

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