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Critical role of PPARγ in myeloid-derived suppressor cell-stimulated cancer cell proliferation and metastasis
Lysosomal acid lipase (LAL) is a key enzyme controlling neutral lipid metabolic signaling in myeloid-derived suppressor cells (MDSCs). MDSCs from LAL-deficient (lal(−/−)) mice directly stimulate cancer cell proliferation. PPARγ ligand treatment inhibited lal(−/−) MDSCs stimulation of tumor cell grow...
Autores principales: | Zhao, Ting, Du, Hong, Blum, Janice S., Yan, Cong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811478/ https://www.ncbi.nlm.nih.gov/pubmed/26625314 |
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