Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1

Adult T-cell leukemia (ATL) is an often fatal malignancy caused by infection with the complex retrovirus, human T-cell Leukemia Virus, type 1 (HTLV-1). In ATL patient samples, the tumor suppressor, p53, is infrequently mutated; however, it has been shown to be inactivated by the viral protein, Tax....

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Detalles Bibliográficos
Autores principales: Wright, Diana G., Marchal, Claire, Hoang, Kimson, Ankney, John A., Nguyen, Stephanie T., Rushing, Amanda W., Polakowski, Nicholas, Miotto, Benoit, Lemasson, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811490/
https://www.ncbi.nlm.nih.gov/pubmed/26625199

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