Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells

Macroautophagy can promote cellular survival or death depending on the cellular context and its extent. We hypothesized that autophagy induction would synergize with a therapeutic agent targeting the autophagic cargo. To test this hypothesis, we treated breast cancer MDA-MB-231 cells with tamoxifen...

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Detalles Bibliográficos
Autores principales: Chen, Yun-Ru, Tsou, Brittany, Hu, Shuya, Ma, Huimin, Liu, Xiyong, Yen, Yun, Ann, David K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811511/
https://www.ncbi.nlm.nih.gov/pubmed/26675256

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