An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome

In Down syndrome (DS) or trisomy of chromosome 21, the β-amyloid (Aβ) peptide product of the amyloid precursor protein (APP) is present in excess. Evidence points to increased APP gene dose and Aβ as playing a critical role in cognitive difficulties experienced by people with DS. Particularly, Aβ is...

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Detalles Bibliográficos
Autores principales: Belichenko, Pavel V., Madani, Rime, Rey-Bellet, Lorianne, Pihlgren, Maria, Becker, Ann, Plassard, Adeline, Vuillermot, Stephanie, Giriens, Valérie, Nosheny, Rachel L., Kleschevnikov, Alexander M., Valletta, Janice S., Bengtsson, Sara K. S., Linke, Gordon R., Maloney, Michael T., Hickman, David T., Reis, Pedro, Granet, Anne, Mlaki, Dorin, Lopez-Deber, Maria Pilar, Do, Long, Singhal, Nishant, Masliah, Eliezer, Pearn, Matthew L., Pfeifer, Andrea, Muhs, Andreas, Mobley, William C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811554/
https://www.ncbi.nlm.nih.gov/pubmed/27023444
http://dx.doi.org/10.1371/journal.pone.0152471

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