Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes

Embryonal Rhabdomyosarcoma (ERMS) and Undifferentiated Pleomorphic Sarcoma (UPS) are distinct sarcoma subtypes. Here we investigate the relevance of the satellite cell (SC) niche in sarcoma development by using Hepatocyte Growth Factor (HGF) to perturb the niche microenvironment. In a Pax7 wild type...

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Detalles Bibliográficos
Autores principales: Morena, Deborah, Maestro, Nicola, Bersani, Francesca, Forni, Paolo Emanuele, Lingua, Marcello Francesco, Foglizzo, Valentina, Šćepanović, Petar, Miretti, Silvia, Morotti, Alessandro, Shern, Jack F, Khan, Javed, Ala, Ugo, Provero, Paolo, Sala, Valentina, Crepaldi, Tiziana, Gasparini, Patrizia, Casanova, Michela, Ferrari, Andrea, Sozzi, Gabriella, Chiarle, Roberto, Ponzetto, Carola, Taulli, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811764/
https://www.ncbi.nlm.nih.gov/pubmed/26987019
http://dx.doi.org/10.7554/eLife.12116

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