Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity

Targeted sequencing of sixteen SLE risk loci among 1349 Caucasian cases and controls produced a comprehensive dataset of the variations causing susceptibility to systemic lupus erythematosus (SLE). Two independent disease association signals in the HLA-D region identified two regulatory regions cont...

Descripción completa

Detalles Bibliográficos
Autores principales: Raj, Prithvi, Rai, Ekta, Song, Ran, Khan, Shaheen, Wakeland, Benjamin E, Viswanathan, Kasthuribai, Arana, Carlos, Liang, Chaoying, Zhang, Bo, Dozmorov, Igor, Carr-Johnson, Ferdicia, Mitrovic, Mitja, Wiley, Graham B, Kelly, Jennifer A, Lauwerys, Bernard R, Olsen, Nancy J, Cotsapas, Chris, Garcia, Christine K, Wise, Carol A, Harley, John B, Nath, Swapan K, James, Judith A, Jacob, Chaim O, Tsao, Betty P, Pasare, Chandrashekhar, Karp, David R, Li, Quan Zhen, Gaffney, Patrick M, Wakeland, Edward K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Genomics and Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811771/
https://www.ncbi.nlm.nih.gov/pubmed/26880555
http://dx.doi.org/10.7554/eLife.12089

Ejemplares similares

Ejemplares similares