Tenofovir Disoproxil Fumarate Fails to Prevent HIV Acquisition or the Establishment of a Viral Reservoir: Two Case Reports

The use of antiretrovirals as pre-exposure prophylaxis (PrEP) is highly efficacious in HIV prevention. The World Health Organization recently recommended Truvada(®) (Gilead Sciences, Inc.) or tenofovir disoproxil fumarate (TDF) for high-risk individuals, with limited data for single-agent TDF PrEP i...

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Autores principales: Fox, Julie, Brady, Michael, Alexander, Hannah, Davies, Olubanke, Robinson, Nicola, Pace, Mathew, Else, Laura, Cason, John, Khoo, Saye, Back, David, Fidler, Sarah, Frater, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811833/
https://www.ncbi.nlm.nih.gov/pubmed/26746652
http://dx.doi.org/10.1007/s40121-015-0102-x
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author Fox, Julie
Brady, Michael
Alexander, Hannah
Davies, Olubanke
Robinson, Nicola
Pace, Mathew
Else, Laura
Cason, John
Khoo, Saye
Back, David
Fidler, Sarah
Frater, John
author_facet Fox, Julie
Brady, Michael
Alexander, Hannah
Davies, Olubanke
Robinson, Nicola
Pace, Mathew
Else, Laura
Cason, John
Khoo, Saye
Back, David
Fidler, Sarah
Frater, John
author_sort Fox, Julie
collection PubMed
description The use of antiretrovirals as pre-exposure prophylaxis (PrEP) is highly efficacious in HIV prevention. The World Health Organization recently recommended Truvada(®) (Gilead Sciences, Inc.) or tenofovir disoproxil fumarate (TDF) for high-risk individuals, with limited data for single-agent TDF PrEP in men who have sex with men (MSM). We report two cases of TDF PrEP failure in MSM who had received long-term TDF for hepatitis B infection and had therapeutic levels of drug immediately after HIV acquisition. Rapid antiretroviral intensification at diagnosis of acute HIV infection failed to limit immune dysfunction or prevent the establishment of a viral reservoir. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40121-015-0102-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-48118332016-04-09 Tenofovir Disoproxil Fumarate Fails to Prevent HIV Acquisition or the Establishment of a Viral Reservoir: Two Case Reports Fox, Julie Brady, Michael Alexander, Hannah Davies, Olubanke Robinson, Nicola Pace, Mathew Else, Laura Cason, John Khoo, Saye Back, David Fidler, Sarah Frater, John Infect Dis Ther Case Report The use of antiretrovirals as pre-exposure prophylaxis (PrEP) is highly efficacious in HIV prevention. The World Health Organization recently recommended Truvada(®) (Gilead Sciences, Inc.) or tenofovir disoproxil fumarate (TDF) for high-risk individuals, with limited data for single-agent TDF PrEP in men who have sex with men (MSM). We report two cases of TDF PrEP failure in MSM who had received long-term TDF for hepatitis B infection and had therapeutic levels of drug immediately after HIV acquisition. Rapid antiretroviral intensification at diagnosis of acute HIV infection failed to limit immune dysfunction or prevent the establishment of a viral reservoir. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40121-015-0102-x) contains supplementary material, which is available to authorized users. Springer Healthcare 2016-01-09 2016-03 /pmc/articles/PMC4811833/ /pubmed/26746652 http://dx.doi.org/10.1007/s40121-015-0102-x Text en © The Author(s) 2015 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Fox, Julie
Brady, Michael
Alexander, Hannah
Davies, Olubanke
Robinson, Nicola
Pace, Mathew
Else, Laura
Cason, John
Khoo, Saye
Back, David
Fidler, Sarah
Frater, John
Tenofovir Disoproxil Fumarate Fails to Prevent HIV Acquisition or the Establishment of a Viral Reservoir: Two Case Reports
title Tenofovir Disoproxil Fumarate Fails to Prevent HIV Acquisition or the Establishment of a Viral Reservoir: Two Case Reports
title_full Tenofovir Disoproxil Fumarate Fails to Prevent HIV Acquisition or the Establishment of a Viral Reservoir: Two Case Reports
title_fullStr Tenofovir Disoproxil Fumarate Fails to Prevent HIV Acquisition or the Establishment of a Viral Reservoir: Two Case Reports
title_full_unstemmed Tenofovir Disoproxil Fumarate Fails to Prevent HIV Acquisition or the Establishment of a Viral Reservoir: Two Case Reports
title_short Tenofovir Disoproxil Fumarate Fails to Prevent HIV Acquisition or the Establishment of a Viral Reservoir: Two Case Reports
title_sort tenofovir disoproxil fumarate fails to prevent hiv acquisition or the establishment of a viral reservoir: two case reports
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811833/
https://www.ncbi.nlm.nih.gov/pubmed/26746652
http://dx.doi.org/10.1007/s40121-015-0102-x
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