Two echinocandin-resistant Candida glabrata FKS mutants from South Africa

Echinocandins are recommended as first-line agents to treat invasive infections caused by Candida glabrata since this organism is inherently less susceptible to azoles. However, resistance to echinocandins has been described in C. glabrata due to amino acid changes in the hotspot regions of the FKS1...

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Autores principales: Naicker, Serisha D., Magobo, Rindidzani E., Zulu, Thokozile G., Maphanga, Tsidiso G., Luthuli, Nkosinathi, Lowman, Warren, Govender, Nelesh P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811853/
https://www.ncbi.nlm.nih.gov/pubmed/27069849
http://dx.doi.org/10.1016/j.mmcr.2016.03.004
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author Naicker, Serisha D.
Magobo, Rindidzani E.
Zulu, Thokozile G.
Maphanga, Tsidiso G.
Luthuli, Nkosinathi
Lowman, Warren
Govender, Nelesh P.
author_facet Naicker, Serisha D.
Magobo, Rindidzani E.
Zulu, Thokozile G.
Maphanga, Tsidiso G.
Luthuli, Nkosinathi
Lowman, Warren
Govender, Nelesh P.
author_sort Naicker, Serisha D.
collection PubMed
description Echinocandins are recommended as first-line agents to treat invasive infections caused by Candida glabrata since this organism is inherently less susceptible to azoles. However, resistance to echinocandins has been described in C. glabrata due to amino acid changes in the hotspot regions of the FKS1 and FKS2 genes. In this report, we describe the first two South African C. glabrata isolates with echinocandin resistance mediated by mutations in the FKS2 gene. Both isolates were cultured from urine specimens from private-sector patients.
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spelling pubmed-48118532016-04-11 Two echinocandin-resistant Candida glabrata FKS mutants from South Africa Naicker, Serisha D. Magobo, Rindidzani E. Zulu, Thokozile G. Maphanga, Tsidiso G. Luthuli, Nkosinathi Lowman, Warren Govender, Nelesh P. Med Mycol Case Rep Case Report Echinocandins are recommended as first-line agents to treat invasive infections caused by Candida glabrata since this organism is inherently less susceptible to azoles. However, resistance to echinocandins has been described in C. glabrata due to amino acid changes in the hotspot regions of the FKS1 and FKS2 genes. In this report, we describe the first two South African C. glabrata isolates with echinocandin resistance mediated by mutations in the FKS2 gene. Both isolates were cultured from urine specimens from private-sector patients. Elsevier 2016-03-21 /pmc/articles/PMC4811853/ /pubmed/27069849 http://dx.doi.org/10.1016/j.mmcr.2016.03.004 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Naicker, Serisha D.
Magobo, Rindidzani E.
Zulu, Thokozile G.
Maphanga, Tsidiso G.
Luthuli, Nkosinathi
Lowman, Warren
Govender, Nelesh P.
Two echinocandin-resistant Candida glabrata FKS mutants from South Africa
title Two echinocandin-resistant Candida glabrata FKS mutants from South Africa
title_full Two echinocandin-resistant Candida glabrata FKS mutants from South Africa
title_fullStr Two echinocandin-resistant Candida glabrata FKS mutants from South Africa
title_full_unstemmed Two echinocandin-resistant Candida glabrata FKS mutants from South Africa
title_short Two echinocandin-resistant Candida glabrata FKS mutants from South Africa
title_sort two echinocandin-resistant candida glabrata fks mutants from south africa
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811853/
https://www.ncbi.nlm.nih.gov/pubmed/27069849
http://dx.doi.org/10.1016/j.mmcr.2016.03.004
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