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Behavioral and EEG Evidence for Auditory Memory Suppression

The neural basis of motivated forgetting using the Think/No-Think (TNT) paradigm is receiving increased attention with a particular focus on the mechanisms that enable memory suppression. However, most TNT studies have been limited to the visual domain. To assess whether and to what extent direct me...

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Autores principales: Cano, Maya E., Knight, Robert T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811890/
https://www.ncbi.nlm.nih.gov/pubmed/27064461
http://dx.doi.org/10.3389/fnhum.2016.00133
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author Cano, Maya E.
Knight, Robert T.
author_facet Cano, Maya E.
Knight, Robert T.
author_sort Cano, Maya E.
collection PubMed
description The neural basis of motivated forgetting using the Think/No-Think (TNT) paradigm is receiving increased attention with a particular focus on the mechanisms that enable memory suppression. However, most TNT studies have been limited to the visual domain. To assess whether and to what extent direct memory suppression extends across sensory modalities, we examined behavioral and electroencephalographic (EEG) effects of auditory TNT in healthy young adults by adapting the TNT paradigm to the auditory modality. Behaviorally, suppression of memory strength was indexed by prolonged response time (RTs) during the retrieval of subsequently remembered No-Think words. We examined task-related EEG activity of both attempted memory retrieval and inhibition of a previously learned target word during the presentation of its paired associate. Event-related EEG responses revealed two main findings: (1) a centralized Think > No-Think positivity during auditory word presentation (from approximately 0–500 ms); and (2) a sustained Think positivity over parietal electrodes beginning at approximately 600 ms reflecting the memory retrieval effect which was significantly reduced for No-Think words. In addition, word-locked theta (4–8 Hz) power was initially greater for No-Think compared to Think during auditory word presentation over fronto-central electrodes. This was followed by a posterior theta increase indexing successful memory retrieval in the Think condition. The observed event-related potential pattern and theta power analysis are similar to that reported in visual TNT studies and support a modality non-specific mechanism for memory inhibition. The EEG data also provide evidence supporting differing roles and time courses of frontal and parietal regions in the flexible control of auditory memory.
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spelling pubmed-48118902016-04-08 Behavioral and EEG Evidence for Auditory Memory Suppression Cano, Maya E. Knight, Robert T. Front Hum Neurosci Neuroscience The neural basis of motivated forgetting using the Think/No-Think (TNT) paradigm is receiving increased attention with a particular focus on the mechanisms that enable memory suppression. However, most TNT studies have been limited to the visual domain. To assess whether and to what extent direct memory suppression extends across sensory modalities, we examined behavioral and electroencephalographic (EEG) effects of auditory TNT in healthy young adults by adapting the TNT paradigm to the auditory modality. Behaviorally, suppression of memory strength was indexed by prolonged response time (RTs) during the retrieval of subsequently remembered No-Think words. We examined task-related EEG activity of both attempted memory retrieval and inhibition of a previously learned target word during the presentation of its paired associate. Event-related EEG responses revealed two main findings: (1) a centralized Think > No-Think positivity during auditory word presentation (from approximately 0–500 ms); and (2) a sustained Think positivity over parietal electrodes beginning at approximately 600 ms reflecting the memory retrieval effect which was significantly reduced for No-Think words. In addition, word-locked theta (4–8 Hz) power was initially greater for No-Think compared to Think during auditory word presentation over fronto-central electrodes. This was followed by a posterior theta increase indexing successful memory retrieval in the Think condition. The observed event-related potential pattern and theta power analysis are similar to that reported in visual TNT studies and support a modality non-specific mechanism for memory inhibition. The EEG data also provide evidence supporting differing roles and time courses of frontal and parietal regions in the flexible control of auditory memory. Frontiers Media S.A. 2016-03-30 /pmc/articles/PMC4811890/ /pubmed/27064461 http://dx.doi.org/10.3389/fnhum.2016.00133 Text en Copyright © 2016 Cano and Knight. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Cano, Maya E.
Knight, Robert T.
Behavioral and EEG Evidence for Auditory Memory Suppression
title Behavioral and EEG Evidence for Auditory Memory Suppression
title_full Behavioral and EEG Evidence for Auditory Memory Suppression
title_fullStr Behavioral and EEG Evidence for Auditory Memory Suppression
title_full_unstemmed Behavioral and EEG Evidence for Auditory Memory Suppression
title_short Behavioral and EEG Evidence for Auditory Memory Suppression
title_sort behavioral and eeg evidence for auditory memory suppression
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811890/
https://www.ncbi.nlm.nih.gov/pubmed/27064461
http://dx.doi.org/10.3389/fnhum.2016.00133
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