Cargando…
Intraeye retinal nerve fiber layer and macular thickness asymmetry measurements for the discrimination of primary open-angle glaucoma and normal tension glaucoma
PURPOSE: The aim of this study was to evaluate the diagnostic capability of intraeye retinal nerve fiber layer (RNFL) thickness and macular thickness (MT) asymmetry measurements for the discrimination of normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG) using spectral domain optic...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812004/ https://www.ncbi.nlm.nih.gov/pubmed/26652244 http://dx.doi.org/10.1016/j.optom.2015.10.002 |
_version_ | 1782424075633688576 |
---|---|
author | Khanal, Safal Davey, Pinakin Gunvant Racette, Lyne Thapa, Madhu |
author_facet | Khanal, Safal Davey, Pinakin Gunvant Racette, Lyne Thapa, Madhu |
author_sort | Khanal, Safal |
collection | PubMed |
description | PURPOSE: The aim of this study was to evaluate the diagnostic capability of intraeye retinal nerve fiber layer (RNFL) thickness and macular thickness (MT) asymmetry measurements for the discrimination of normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT). METHODS: A total of 90 subjects were enrolled including 30 consecutive healthy subjects, 30 consecutive subjects with POAG, and 30 consecutive subjects with NTG. RNFL thicknesses around the optic disc as well as MT measurements were taken with circular and radial SD-OCT scans. Intraeye retinal and MT asymmetry were calculated as the absolute difference between superior and inferior hemispheres of the eye using posterior pole asymmetry analysis protocol. Analysis of variance was used for comparison and areas under the receiver operating characteristic (AROC) were obtained for different parameters among the three diagnostic groups. RESULTS: There was a significant difference in MT asymmetry for all comparison groups (normal-NTG, p < 0.05; normal-POAG, p < 0.001; and NTG-POAG, p < 0.001). Intraeye retinal nerve fiber thickness asymmetry measurements were not different between the groups (normal-NTG, p < 0.187; normal-POAG, p < 0.056; and NTG-POAG, p < 0.837). The area under ROC curves exceeded 0.800 for all the studied parameters, including the MT asymmetry except for intraeye RNFL thickness asymmetry which had the lowest AROC as well as the least sensitivity for identifying subjects with NTG from normal (AROC = 0.626, sensitivity = 30%); POAG from normal (AROC = 0.644, sensitivity = 37%) and NTG from POAG (AROC = 0.533, sensitivity = 13%). CONCLUSION: The intraeye MT asymmetry holds significant potential as a distinguishing parameter for NTG and POAG. |
format | Online Article Text |
id | pubmed-4812004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-48120042016-04-11 Intraeye retinal nerve fiber layer and macular thickness asymmetry measurements for the discrimination of primary open-angle glaucoma and normal tension glaucoma Khanal, Safal Davey, Pinakin Gunvant Racette, Lyne Thapa, Madhu J Optom Original Article PURPOSE: The aim of this study was to evaluate the diagnostic capability of intraeye retinal nerve fiber layer (RNFL) thickness and macular thickness (MT) asymmetry measurements for the discrimination of normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT). METHODS: A total of 90 subjects were enrolled including 30 consecutive healthy subjects, 30 consecutive subjects with POAG, and 30 consecutive subjects with NTG. RNFL thicknesses around the optic disc as well as MT measurements were taken with circular and radial SD-OCT scans. Intraeye retinal and MT asymmetry were calculated as the absolute difference between superior and inferior hemispheres of the eye using posterior pole asymmetry analysis protocol. Analysis of variance was used for comparison and areas under the receiver operating characteristic (AROC) were obtained for different parameters among the three diagnostic groups. RESULTS: There was a significant difference in MT asymmetry for all comparison groups (normal-NTG, p < 0.05; normal-POAG, p < 0.001; and NTG-POAG, p < 0.001). Intraeye retinal nerve fiber thickness asymmetry measurements were not different between the groups (normal-NTG, p < 0.187; normal-POAG, p < 0.056; and NTG-POAG, p < 0.837). The area under ROC curves exceeded 0.800 for all the studied parameters, including the MT asymmetry except for intraeye RNFL thickness asymmetry which had the lowest AROC as well as the least sensitivity for identifying subjects with NTG from normal (AROC = 0.626, sensitivity = 30%); POAG from normal (AROC = 0.644, sensitivity = 37%) and NTG from POAG (AROC = 0.533, sensitivity = 13%). CONCLUSION: The intraeye MT asymmetry holds significant potential as a distinguishing parameter for NTG and POAG. Elsevier 2016 2015-12-01 /pmc/articles/PMC4812004/ /pubmed/26652244 http://dx.doi.org/10.1016/j.optom.2015.10.002 Text en © 2015 Spanish General Council of Optometry. Published by Elsevier España, S.L.U. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Khanal, Safal Davey, Pinakin Gunvant Racette, Lyne Thapa, Madhu Intraeye retinal nerve fiber layer and macular thickness asymmetry measurements for the discrimination of primary open-angle glaucoma and normal tension glaucoma |
title | Intraeye retinal nerve fiber layer and macular thickness asymmetry measurements for the discrimination of primary open-angle glaucoma and normal tension glaucoma |
title_full | Intraeye retinal nerve fiber layer and macular thickness asymmetry measurements for the discrimination of primary open-angle glaucoma and normal tension glaucoma |
title_fullStr | Intraeye retinal nerve fiber layer and macular thickness asymmetry measurements for the discrimination of primary open-angle glaucoma and normal tension glaucoma |
title_full_unstemmed | Intraeye retinal nerve fiber layer and macular thickness asymmetry measurements for the discrimination of primary open-angle glaucoma and normal tension glaucoma |
title_short | Intraeye retinal nerve fiber layer and macular thickness asymmetry measurements for the discrimination of primary open-angle glaucoma and normal tension glaucoma |
title_sort | intraeye retinal nerve fiber layer and macular thickness asymmetry measurements for the discrimination of primary open-angle glaucoma and normal tension glaucoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812004/ https://www.ncbi.nlm.nih.gov/pubmed/26652244 http://dx.doi.org/10.1016/j.optom.2015.10.002 |
work_keys_str_mv | AT khanalsafal intraeyeretinalnervefiberlayerandmacularthicknessasymmetrymeasurementsforthediscriminationofprimaryopenangleglaucomaandnormaltensionglaucoma AT daveypinakingunvant intraeyeretinalnervefiberlayerandmacularthicknessasymmetrymeasurementsforthediscriminationofprimaryopenangleglaucomaandnormaltensionglaucoma AT racettelyne intraeyeretinalnervefiberlayerandmacularthicknessasymmetrymeasurementsforthediscriminationofprimaryopenangleglaucomaandnormaltensionglaucoma AT thapamadhu intraeyeretinalnervefiberlayerandmacularthicknessasymmetrymeasurementsforthediscriminationofprimaryopenangleglaucomaandnormaltensionglaucoma |