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Replicative random mutations as an unproven cause of cancer: A technical comment

A careful molecular biology, epidemiological and mathematical modelling reanalysis of the recently published study titled ‘Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions’ by Cristian Tomasetti and Bert Vogelstein, which was published on...

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Detalles Bibliográficos
Autores principales: BELPOMME, DOMINIQUE, IRIGARAY, PHILIPPE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812174/
https://www.ncbi.nlm.nih.gov/pubmed/27073649
http://dx.doi.org/10.3892/mco.2016.737
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author BELPOMME, DOMINIQUE
IRIGARAY, PHILIPPE
author_facet BELPOMME, DOMINIQUE
IRIGARAY, PHILIPPE
author_sort BELPOMME, DOMINIQUE
collection PubMed
description A careful molecular biology, epidemiological and mathematical modelling reanalysis of the recently published study titled ‘Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions’ by Cristian Tomasetti and Bert Vogelstein, which was published on January 2, 2015 in the distinguished journal Science, led to the conclusion that, contrary to the authors' claim, many cancer types are not caused by replicative random mutations. Rather than the authors' two arbitrarily individualized groups of cancer, a three-group model is herein proposed in the framework of this technical comment, considerably reducing the fraction of cancer cases hypothetically attributable to random mutations.
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spelling pubmed-48121742016-04-12 Replicative random mutations as an unproven cause of cancer: A technical comment BELPOMME, DOMINIQUE IRIGARAY, PHILIPPE Mol Clin Oncol Articles A careful molecular biology, epidemiological and mathematical modelling reanalysis of the recently published study titled ‘Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions’ by Cristian Tomasetti and Bert Vogelstein, which was published on January 2, 2015 in the distinguished journal Science, led to the conclusion that, contrary to the authors' claim, many cancer types are not caused by replicative random mutations. Rather than the authors' two arbitrarily individualized groups of cancer, a three-group model is herein proposed in the framework of this technical comment, considerably reducing the fraction of cancer cases hypothetically attributable to random mutations. D.A. Spandidos 2016-04 2016-01-25 /pmc/articles/PMC4812174/ /pubmed/27073649 http://dx.doi.org/10.3892/mco.2016.737 Text en Copyright: © Belpomme et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
BELPOMME, DOMINIQUE
IRIGARAY, PHILIPPE
Replicative random mutations as an unproven cause of cancer: A technical comment
title Replicative random mutations as an unproven cause of cancer: A technical comment
title_full Replicative random mutations as an unproven cause of cancer: A technical comment
title_fullStr Replicative random mutations as an unproven cause of cancer: A technical comment
title_full_unstemmed Replicative random mutations as an unproven cause of cancer: A technical comment
title_short Replicative random mutations as an unproven cause of cancer: A technical comment
title_sort replicative random mutations as an unproven cause of cancer: a technical comment
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812174/
https://www.ncbi.nlm.nih.gov/pubmed/27073649
http://dx.doi.org/10.3892/mco.2016.737
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