Cargando…
Replicative random mutations as an unproven cause of cancer: A technical comment
A careful molecular biology, epidemiological and mathematical modelling reanalysis of the recently published study titled ‘Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions’ by Cristian Tomasetti and Bert Vogelstein, which was published on...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812174/ https://www.ncbi.nlm.nih.gov/pubmed/27073649 http://dx.doi.org/10.3892/mco.2016.737 |
_version_ | 1782424103667367936 |
---|---|
author | BELPOMME, DOMINIQUE IRIGARAY, PHILIPPE |
author_facet | BELPOMME, DOMINIQUE IRIGARAY, PHILIPPE |
author_sort | BELPOMME, DOMINIQUE |
collection | PubMed |
description | A careful molecular biology, epidemiological and mathematical modelling reanalysis of the recently published study titled ‘Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions’ by Cristian Tomasetti and Bert Vogelstein, which was published on January 2, 2015 in the distinguished journal Science, led to the conclusion that, contrary to the authors' claim, many cancer types are not caused by replicative random mutations. Rather than the authors' two arbitrarily individualized groups of cancer, a three-group model is herein proposed in the framework of this technical comment, considerably reducing the fraction of cancer cases hypothetically attributable to random mutations. |
format | Online Article Text |
id | pubmed-4812174 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-48121742016-04-12 Replicative random mutations as an unproven cause of cancer: A technical comment BELPOMME, DOMINIQUE IRIGARAY, PHILIPPE Mol Clin Oncol Articles A careful molecular biology, epidemiological and mathematical modelling reanalysis of the recently published study titled ‘Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions’ by Cristian Tomasetti and Bert Vogelstein, which was published on January 2, 2015 in the distinguished journal Science, led to the conclusion that, contrary to the authors' claim, many cancer types are not caused by replicative random mutations. Rather than the authors' two arbitrarily individualized groups of cancer, a three-group model is herein proposed in the framework of this technical comment, considerably reducing the fraction of cancer cases hypothetically attributable to random mutations. D.A. Spandidos 2016-04 2016-01-25 /pmc/articles/PMC4812174/ /pubmed/27073649 http://dx.doi.org/10.3892/mco.2016.737 Text en Copyright: © Belpomme et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles BELPOMME, DOMINIQUE IRIGARAY, PHILIPPE Replicative random mutations as an unproven cause of cancer: A technical comment |
title | Replicative random mutations as an unproven cause of cancer: A technical comment |
title_full | Replicative random mutations as an unproven cause of cancer: A technical comment |
title_fullStr | Replicative random mutations as an unproven cause of cancer: A technical comment |
title_full_unstemmed | Replicative random mutations as an unproven cause of cancer: A technical comment |
title_short | Replicative random mutations as an unproven cause of cancer: A technical comment |
title_sort | replicative random mutations as an unproven cause of cancer: a technical comment |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812174/ https://www.ncbi.nlm.nih.gov/pubmed/27073649 http://dx.doi.org/10.3892/mco.2016.737 |
work_keys_str_mv | AT belpommedominique replicativerandommutationsasanunprovencauseofcanceratechnicalcomment AT irigarayphilippe replicativerandommutationsasanunprovencauseofcanceratechnicalcomment |