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Photopsias during Systemic Bevacizumab Therapy
Background. The authors describe a case of recurrent photopsias in a 56-year-old woman following repeat treatments with systemic intravenous bevacizumab for stage IV ovarian cancer. To our knowledge, this is the first report of photopsias following systemic bevacizumab treatments in a patient with a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812264/ https://www.ncbi.nlm.nih.gov/pubmed/27069702 http://dx.doi.org/10.1155/2016/1926178 |
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author | Leisy, Heather Ahmad, Meleha Smith, R. Theodore |
author_facet | Leisy, Heather Ahmad, Meleha Smith, R. Theodore |
author_sort | Leisy, Heather |
collection | PubMed |
description | Background. The authors describe a case of recurrent photopsias in a 56-year-old woman following repeat treatments with systemic intravenous bevacizumab for stage IV ovarian cancer. To our knowledge, this is the first report of photopsias following systemic bevacizumab treatments in a patient with a normal eye exam. Case Presentation. A 56-year-old Caucasian female complained of onset of floaters and flashes in the temporal peripheral field of the right eye 1 day after receiving intravenous of 30 g of 25 mg/mL of systemic bevacizumab for treatment of stage IV ovarian cancer. Ophthalmic examination, including dilated fundus exam, spectral domain optical coherence tomography (SD-OCT) of the optic nerve head, and enhanced depth imaging SD-OCT of the macula, revealed no significant abnormalities. Possible mechanisms are reviewed. Conclusion. We propose that patients who undergo intravenous bevacizumab treatments are questioned for any ocular symptoms and that more systematic evaluations of retinal nerve fiber layer and choroidal effects are obtained in those patients who are on long-term treatment at high doses. |
format | Online Article Text |
id | pubmed-4812264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48122642016-04-11 Photopsias during Systemic Bevacizumab Therapy Leisy, Heather Ahmad, Meleha Smith, R. Theodore Case Rep Ophthalmol Med Case Report Background. The authors describe a case of recurrent photopsias in a 56-year-old woman following repeat treatments with systemic intravenous bevacizumab for stage IV ovarian cancer. To our knowledge, this is the first report of photopsias following systemic bevacizumab treatments in a patient with a normal eye exam. Case Presentation. A 56-year-old Caucasian female complained of onset of floaters and flashes in the temporal peripheral field of the right eye 1 day after receiving intravenous of 30 g of 25 mg/mL of systemic bevacizumab for treatment of stage IV ovarian cancer. Ophthalmic examination, including dilated fundus exam, spectral domain optical coherence tomography (SD-OCT) of the optic nerve head, and enhanced depth imaging SD-OCT of the macula, revealed no significant abnormalities. Possible mechanisms are reviewed. Conclusion. We propose that patients who undergo intravenous bevacizumab treatments are questioned for any ocular symptoms and that more systematic evaluations of retinal nerve fiber layer and choroidal effects are obtained in those patients who are on long-term treatment at high doses. Hindawi Publishing Corporation 2016 2016-03-16 /pmc/articles/PMC4812264/ /pubmed/27069702 http://dx.doi.org/10.1155/2016/1926178 Text en Copyright © 2016 Heather Leisy et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Leisy, Heather Ahmad, Meleha Smith, R. Theodore Photopsias during Systemic Bevacizumab Therapy |
title | Photopsias during Systemic Bevacizumab Therapy |
title_full | Photopsias during Systemic Bevacizumab Therapy |
title_fullStr | Photopsias during Systemic Bevacizumab Therapy |
title_full_unstemmed | Photopsias during Systemic Bevacizumab Therapy |
title_short | Photopsias during Systemic Bevacizumab Therapy |
title_sort | photopsias during systemic bevacizumab therapy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812264/ https://www.ncbi.nlm.nih.gov/pubmed/27069702 http://dx.doi.org/10.1155/2016/1926178 |
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