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Photopsias during Systemic Bevacizumab Therapy

Background. The authors describe a case of recurrent photopsias in a 56-year-old woman following repeat treatments with systemic intravenous bevacizumab for stage IV ovarian cancer. To our knowledge, this is the first report of photopsias following systemic bevacizumab treatments in a patient with a...

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Autores principales: Leisy, Heather, Ahmad, Meleha, Smith, R. Theodore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812264/
https://www.ncbi.nlm.nih.gov/pubmed/27069702
http://dx.doi.org/10.1155/2016/1926178
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author Leisy, Heather
Ahmad, Meleha
Smith, R. Theodore
author_facet Leisy, Heather
Ahmad, Meleha
Smith, R. Theodore
author_sort Leisy, Heather
collection PubMed
description Background. The authors describe a case of recurrent photopsias in a 56-year-old woman following repeat treatments with systemic intravenous bevacizumab for stage IV ovarian cancer. To our knowledge, this is the first report of photopsias following systemic bevacizumab treatments in a patient with a normal eye exam. Case Presentation. A 56-year-old Caucasian female complained of onset of floaters and flashes in the temporal peripheral field of the right eye 1 day after receiving intravenous of 30 g of 25 mg/mL of systemic bevacizumab for treatment of stage IV ovarian cancer. Ophthalmic examination, including dilated fundus exam, spectral domain optical coherence tomography (SD-OCT) of the optic nerve head, and enhanced depth imaging SD-OCT of the macula, revealed no significant abnormalities. Possible mechanisms are reviewed. Conclusion. We propose that patients who undergo intravenous bevacizumab treatments are questioned for any ocular symptoms and that more systematic evaluations of retinal nerve fiber layer and choroidal effects are obtained in those patients who are on long-term treatment at high doses.
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spelling pubmed-48122642016-04-11 Photopsias during Systemic Bevacizumab Therapy Leisy, Heather Ahmad, Meleha Smith, R. Theodore Case Rep Ophthalmol Med Case Report Background. The authors describe a case of recurrent photopsias in a 56-year-old woman following repeat treatments with systemic intravenous bevacizumab for stage IV ovarian cancer. To our knowledge, this is the first report of photopsias following systemic bevacizumab treatments in a patient with a normal eye exam. Case Presentation. A 56-year-old Caucasian female complained of onset of floaters and flashes in the temporal peripheral field of the right eye 1 day after receiving intravenous of 30 g of 25 mg/mL of systemic bevacizumab for treatment of stage IV ovarian cancer. Ophthalmic examination, including dilated fundus exam, spectral domain optical coherence tomography (SD-OCT) of the optic nerve head, and enhanced depth imaging SD-OCT of the macula, revealed no significant abnormalities. Possible mechanisms are reviewed. Conclusion. We propose that patients who undergo intravenous bevacizumab treatments are questioned for any ocular symptoms and that more systematic evaluations of retinal nerve fiber layer and choroidal effects are obtained in those patients who are on long-term treatment at high doses. Hindawi Publishing Corporation 2016 2016-03-16 /pmc/articles/PMC4812264/ /pubmed/27069702 http://dx.doi.org/10.1155/2016/1926178 Text en Copyright © 2016 Heather Leisy et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Leisy, Heather
Ahmad, Meleha
Smith, R. Theodore
Photopsias during Systemic Bevacizumab Therapy
title Photopsias during Systemic Bevacizumab Therapy
title_full Photopsias during Systemic Bevacizumab Therapy
title_fullStr Photopsias during Systemic Bevacizumab Therapy
title_full_unstemmed Photopsias during Systemic Bevacizumab Therapy
title_short Photopsias during Systemic Bevacizumab Therapy
title_sort photopsias during systemic bevacizumab therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812264/
https://www.ncbi.nlm.nih.gov/pubmed/27069702
http://dx.doi.org/10.1155/2016/1926178
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