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Effects of hydrogen-rich water on depressive-like behavior in mice

Emerging evidence suggests that neuroinflammation and oxidative stress may be major contributors to major depressive disorder (MDD). Patients or animal models of depression show significant increase of proinflammatory cytokine interleukin-1β (IL-1β) and oxidative stress biomarkers in the periphery o...

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Autores principales: Zhang, Yi, Su, Wen-Jun, Chen, Ying, Wu, Teng-Yun, Gong, Hong, Shen, Xiao-Liang, Wang, Yun-Xia, Sun, Xue-Jun, Jiang, Chun-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812321/
https://www.ncbi.nlm.nih.gov/pubmed/27026206
http://dx.doi.org/10.1038/srep23742
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author Zhang, Yi
Su, Wen-Jun
Chen, Ying
Wu, Teng-Yun
Gong, Hong
Shen, Xiao-Liang
Wang, Yun-Xia
Sun, Xue-Jun
Jiang, Chun-Lei
author_facet Zhang, Yi
Su, Wen-Jun
Chen, Ying
Wu, Teng-Yun
Gong, Hong
Shen, Xiao-Liang
Wang, Yun-Xia
Sun, Xue-Jun
Jiang, Chun-Lei
author_sort Zhang, Yi
collection PubMed
description Emerging evidence suggests that neuroinflammation and oxidative stress may be major contributors to major depressive disorder (MDD). Patients or animal models of depression show significant increase of proinflammatory cytokine interleukin-1β (IL-1β) and oxidative stress biomarkers in the periphery or central nervous system (CNS). Recent studies show that hydrogen selectively reduces cytotoxic oxygen radicals, and hydrogen-rich saline potentially suppresses the production of several proinflammatory mediators. Since current depression medications are accompanied by a wide spectrum of side effects, novel preventative or therapeutic measures with fewer side effects might have a promising future. We investigated the effects of drinking hydrogen-rich water on the depressive-like behavior in mice and its underlying mechanisms. Our study show that hydrogen-rich water treatment prevents chronic unpredictable mild stress (CUMS) induced depressive-like behavior. CUMS induced elevation in IL-1β protein levels in the hippocampus, and the cortex was significantly attenuated after 4 weeks of feeding the mice hydrogen-rich water. Over-expression of caspase-1 (the IL-1β converting enzyme) and excessive reactive oxygen species (ROS) production in the hippocampus and prefrontal cortex (PFC) was successfully suppressed by hydrogen-rich water treatment. Our data suggest that the beneficial effects of hydrogen-rich water on depressive-like behavior may be mediated by suppression of the inflammasome activation resulting in attenuated protein IL-1β and ROS production.
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spelling pubmed-48123212016-04-04 Effects of hydrogen-rich water on depressive-like behavior in mice Zhang, Yi Su, Wen-Jun Chen, Ying Wu, Teng-Yun Gong, Hong Shen, Xiao-Liang Wang, Yun-Xia Sun, Xue-Jun Jiang, Chun-Lei Sci Rep Article Emerging evidence suggests that neuroinflammation and oxidative stress may be major contributors to major depressive disorder (MDD). Patients or animal models of depression show significant increase of proinflammatory cytokine interleukin-1β (IL-1β) and oxidative stress biomarkers in the periphery or central nervous system (CNS). Recent studies show that hydrogen selectively reduces cytotoxic oxygen radicals, and hydrogen-rich saline potentially suppresses the production of several proinflammatory mediators. Since current depression medications are accompanied by a wide spectrum of side effects, novel preventative or therapeutic measures with fewer side effects might have a promising future. We investigated the effects of drinking hydrogen-rich water on the depressive-like behavior in mice and its underlying mechanisms. Our study show that hydrogen-rich water treatment prevents chronic unpredictable mild stress (CUMS) induced depressive-like behavior. CUMS induced elevation in IL-1β protein levels in the hippocampus, and the cortex was significantly attenuated after 4 weeks of feeding the mice hydrogen-rich water. Over-expression of caspase-1 (the IL-1β converting enzyme) and excessive reactive oxygen species (ROS) production in the hippocampus and prefrontal cortex (PFC) was successfully suppressed by hydrogen-rich water treatment. Our data suggest that the beneficial effects of hydrogen-rich water on depressive-like behavior may be mediated by suppression of the inflammasome activation resulting in attenuated protein IL-1β and ROS production. Nature Publishing Group 2016-03-30 /pmc/articles/PMC4812321/ /pubmed/27026206 http://dx.doi.org/10.1038/srep23742 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Yi
Su, Wen-Jun
Chen, Ying
Wu, Teng-Yun
Gong, Hong
Shen, Xiao-Liang
Wang, Yun-Xia
Sun, Xue-Jun
Jiang, Chun-Lei
Effects of hydrogen-rich water on depressive-like behavior in mice
title Effects of hydrogen-rich water on depressive-like behavior in mice
title_full Effects of hydrogen-rich water on depressive-like behavior in mice
title_fullStr Effects of hydrogen-rich water on depressive-like behavior in mice
title_full_unstemmed Effects of hydrogen-rich water on depressive-like behavior in mice
title_short Effects of hydrogen-rich water on depressive-like behavior in mice
title_sort effects of hydrogen-rich water on depressive-like behavior in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812321/
https://www.ncbi.nlm.nih.gov/pubmed/27026206
http://dx.doi.org/10.1038/srep23742
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