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Lamina Associated Polypeptide 1 (LAP1) Interactome and Its Functional Features

Lamina-associated polypeptide 1 (LAP1) is a type II transmembrane protein of the inner nuclear membrane encoded by the human gene TOR1AIP1. LAP1 is involved in maintaining the nuclear envelope structure and appears be involved in the positioning of lamins and chromatin. To date, LAP1’s precise funct...

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Autores principales: Serrano, Joana B., da Cruz e Silva, Odete A. B., Rebelo, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812414/
https://www.ncbi.nlm.nih.gov/pubmed/26784240
http://dx.doi.org/10.3390/membranes6010008
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author Serrano, Joana B.
da Cruz e Silva, Odete A. B.
Rebelo, Sandra
author_facet Serrano, Joana B.
da Cruz e Silva, Odete A. B.
Rebelo, Sandra
author_sort Serrano, Joana B.
collection PubMed
description Lamina-associated polypeptide 1 (LAP1) is a type II transmembrane protein of the inner nuclear membrane encoded by the human gene TOR1AIP1. LAP1 is involved in maintaining the nuclear envelope structure and appears be involved in the positioning of lamins and chromatin. To date, LAP1’s precise function has not been fully elucidated but analysis of its interacting proteins will permit unraveling putative associations to specific cellular pathways and cellular processes. By assessing public databases it was possible to identify the LAP1 interactome, and this was curated. In total, 41 interactions were identified. Several functionally relevant proteins, such as TRF2, TERF2IP, RIF1, ATM, MAD2L1 and MAD2L1BP were identified and these support the putative functions proposed for LAP1. Furthermore, by making use of the Ingenuity Pathways Analysis tool and submitting the LAP1 interactors, the top two canonical pathways were “Telomerase signalling” and “Telomere Extension by Telomerase” and the top functions “Cell Morphology”, “Cellular Assembly and Organization” and “DNA Replication, Recombination, and Repair”. Once again, putative LAP1 functions are reinforced but novel functions are emerging.
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spelling pubmed-48124142016-04-06 Lamina Associated Polypeptide 1 (LAP1) Interactome and Its Functional Features Serrano, Joana B. da Cruz e Silva, Odete A. B. Rebelo, Sandra Membranes (Basel) Article Lamina-associated polypeptide 1 (LAP1) is a type II transmembrane protein of the inner nuclear membrane encoded by the human gene TOR1AIP1. LAP1 is involved in maintaining the nuclear envelope structure and appears be involved in the positioning of lamins and chromatin. To date, LAP1’s precise function has not been fully elucidated but analysis of its interacting proteins will permit unraveling putative associations to specific cellular pathways and cellular processes. By assessing public databases it was possible to identify the LAP1 interactome, and this was curated. In total, 41 interactions were identified. Several functionally relevant proteins, such as TRF2, TERF2IP, RIF1, ATM, MAD2L1 and MAD2L1BP were identified and these support the putative functions proposed for LAP1. Furthermore, by making use of the Ingenuity Pathways Analysis tool and submitting the LAP1 interactors, the top two canonical pathways were “Telomerase signalling” and “Telomere Extension by Telomerase” and the top functions “Cell Morphology”, “Cellular Assembly and Organization” and “DNA Replication, Recombination, and Repair”. Once again, putative LAP1 functions are reinforced but novel functions are emerging. MDPI 2016-01-15 /pmc/articles/PMC4812414/ /pubmed/26784240 http://dx.doi.org/10.3390/membranes6010008 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Serrano, Joana B.
da Cruz e Silva, Odete A. B.
Rebelo, Sandra
Lamina Associated Polypeptide 1 (LAP1) Interactome and Its Functional Features
title Lamina Associated Polypeptide 1 (LAP1) Interactome and Its Functional Features
title_full Lamina Associated Polypeptide 1 (LAP1) Interactome and Its Functional Features
title_fullStr Lamina Associated Polypeptide 1 (LAP1) Interactome and Its Functional Features
title_full_unstemmed Lamina Associated Polypeptide 1 (LAP1) Interactome and Its Functional Features
title_short Lamina Associated Polypeptide 1 (LAP1) Interactome and Its Functional Features
title_sort lamina associated polypeptide 1 (lap1) interactome and its functional features
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812414/
https://www.ncbi.nlm.nih.gov/pubmed/26784240
http://dx.doi.org/10.3390/membranes6010008
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