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The Utility of Allograft Mesenchymal Stem Cells for Spine Fusion: A Literature Review

More than 50% of patients complain of postoperative donor site morbidity following iliac crest bone graft harvest, and recent discoveries have identified adverse outcomes following bone morphogenetic protein use in spine fusion. This has led the spine community to turn toward alternative methods to...

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Detalles Bibliográficos
Autores principales: Lubelski, Daniel, Abdullah, Kalil G., Benzel, Edward C., Mroz, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical Publishers 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813091/
https://www.ncbi.nlm.nih.gov/pubmed/27054055
http://dx.doi.org/10.1055/s-0032-1307263
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author Lubelski, Daniel
Abdullah, Kalil G.
Benzel, Edward C.
Mroz, Thomas E.
author_facet Lubelski, Daniel
Abdullah, Kalil G.
Benzel, Edward C.
Mroz, Thomas E.
author_sort Lubelski, Daniel
collection PubMed
description More than 50% of patients complain of postoperative donor site morbidity following iliac crest bone graft harvest, and recent discoveries have identified adverse outcomes following bone morphogenetic protein use in spine fusion. This has led the spine community to turn toward alternative methods to promote fusion following spine surgery. The present article reviews numerous studies that have shown the osteogenic potential of mesenchymal stem cells (MSCs). MSCs have been used with both in vitro and in vivo models and have involved animal studies ranging from rats to macaque monkeys to successfully induce bone regeneration in lesions of the tibia and spine. There is no fear of graft rejection, as there may be with other allograft materials, because neither undifferentiated nor differentiated MSCs elicit lymphocyte response when transplanted; they tend to alter the cytokine profile to an anti-inflammatory state. Early clinical trials are underway with various commercially available MSC formulations. Although there is much enthusiasm, it is integral that the spine surgery community carefully evaluate the use of MSCs in spine fusion through well-designed and executed studies to determine the efficacy and safety profiles in spine surgery patients.
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spelling pubmed-48130912016-04-06 The Utility of Allograft Mesenchymal Stem Cells for Spine Fusion: A Literature Review Lubelski, Daniel Abdullah, Kalil G. Benzel, Edward C. Mroz, Thomas E. Global Spine J Article More than 50% of patients complain of postoperative donor site morbidity following iliac crest bone graft harvest, and recent discoveries have identified adverse outcomes following bone morphogenetic protein use in spine fusion. This has led the spine community to turn toward alternative methods to promote fusion following spine surgery. The present article reviews numerous studies that have shown the osteogenic potential of mesenchymal stem cells (MSCs). MSCs have been used with both in vitro and in vivo models and have involved animal studies ranging from rats to macaque monkeys to successfully induce bone regeneration in lesions of the tibia and spine. There is no fear of graft rejection, as there may be with other allograft materials, because neither undifferentiated nor differentiated MSCs elicit lymphocyte response when transplanted; they tend to alter the cytokine profile to an anti-inflammatory state. Early clinical trials are underway with various commercially available MSC formulations. Although there is much enthusiasm, it is integral that the spine surgery community carefully evaluate the use of MSCs in spine fusion through well-designed and executed studies to determine the efficacy and safety profiles in spine surgery patients. Thieme Medical Publishers 2012-06 /pmc/articles/PMC4813091/ /pubmed/27054055 http://dx.doi.org/10.1055/s-0032-1307263 Text en © Thieme Medical Publishers
spellingShingle Article
Lubelski, Daniel
Abdullah, Kalil G.
Benzel, Edward C.
Mroz, Thomas E.
The Utility of Allograft Mesenchymal Stem Cells for Spine Fusion: A Literature Review
title The Utility of Allograft Mesenchymal Stem Cells for Spine Fusion: A Literature Review
title_full The Utility of Allograft Mesenchymal Stem Cells for Spine Fusion: A Literature Review
title_fullStr The Utility of Allograft Mesenchymal Stem Cells for Spine Fusion: A Literature Review
title_full_unstemmed The Utility of Allograft Mesenchymal Stem Cells for Spine Fusion: A Literature Review
title_short The Utility of Allograft Mesenchymal Stem Cells for Spine Fusion: A Literature Review
title_sort utility of allograft mesenchymal stem cells for spine fusion: a literature review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813091/
https://www.ncbi.nlm.nih.gov/pubmed/27054055
http://dx.doi.org/10.1055/s-0032-1307263
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