Mycobacterium tuberculosis: Manipulator of Protective Immunity

Mycobacterium tuberculosis (MTB) is one of the most successful pathogens in human history and remains a global health challenge. MTB has evolved a plethora of strategies to evade the immune response sufficiently to survive within the macrophage in a bacterial-immunological equilibrium, yet causes su...

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Detalles Bibliográficos
Autores principales: Korb, Vanessa C., Chuturgoon, Anil A., Moodley, Devapregasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813124/
https://www.ncbi.nlm.nih.gov/pubmed/26927066
http://dx.doi.org/10.3390/ijms17030131
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author Korb, Vanessa C.
Chuturgoon, Anil A.
Moodley, Devapregasan
author_facet Korb, Vanessa C.
Chuturgoon, Anil A.
Moodley, Devapregasan
author_sort Korb, Vanessa C.
collection PubMed
description Mycobacterium tuberculosis (MTB) is one of the most successful pathogens in human history and remains a global health challenge. MTB has evolved a plethora of strategies to evade the immune response sufficiently to survive within the macrophage in a bacterial-immunological equilibrium, yet causes sufficient immunopathology to facilitate its transmission. This review highlights MTB as the driver of disease pathogenesis and presents evidence of the mechanisms by which MTB manipulates the protective immune response into a pathological productive infection.
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spelling pubmed-48131242016-04-06 Mycobacterium tuberculosis: Manipulator of Protective Immunity Korb, Vanessa C. Chuturgoon, Anil A. Moodley, Devapregasan Int J Mol Sci Review Mycobacterium tuberculosis (MTB) is one of the most successful pathogens in human history and remains a global health challenge. MTB has evolved a plethora of strategies to evade the immune response sufficiently to survive within the macrophage in a bacterial-immunological equilibrium, yet causes sufficient immunopathology to facilitate its transmission. This review highlights MTB as the driver of disease pathogenesis and presents evidence of the mechanisms by which MTB manipulates the protective immune response into a pathological productive infection. MDPI 2016-02-25 /pmc/articles/PMC4813124/ /pubmed/26927066 http://dx.doi.org/10.3390/ijms17030131 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Korb, Vanessa C.
Chuturgoon, Anil A.
Moodley, Devapregasan
Mycobacterium tuberculosis: Manipulator of Protective Immunity
title Mycobacterium tuberculosis: Manipulator of Protective Immunity
title_full Mycobacterium tuberculosis: Manipulator of Protective Immunity
title_fullStr Mycobacterium tuberculosis: Manipulator of Protective Immunity
title_full_unstemmed Mycobacterium tuberculosis: Manipulator of Protective Immunity
title_short Mycobacterium tuberculosis: Manipulator of Protective Immunity
title_sort mycobacterium tuberculosis: manipulator of protective immunity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813124/
https://www.ncbi.nlm.nih.gov/pubmed/26927066
http://dx.doi.org/10.3390/ijms17030131
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AT moodleydevapregasan mycobacteriumtuberculosismanipulatorofprotectiveimmunity

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