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Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study
In the present study, we evaluated tumor-infiltrating lymphocytes (TILs) and blood regulatory T lymphocyte (Tregs, CD4+/CD25+/FoxP3+) expression in bladder cancer patients. The number of CD4+, CD8+, CD25+, FoxP3+ and CD20+ TILs was analyzed in association with clinico-pathomorphological features. In...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813149/ https://www.ncbi.nlm.nih.gov/pubmed/26927070 http://dx.doi.org/10.3390/ijms17030285 |
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author | Jóźwicki, Wojciech Brożyna, Anna A. Siekiera, Jerzy Slominski, Andrzej T. |
author_facet | Jóźwicki, Wojciech Brożyna, Anna A. Siekiera, Jerzy Slominski, Andrzej T. |
author_sort | Jóźwicki, Wojciech |
collection | PubMed |
description | In the present study, we evaluated tumor-infiltrating lymphocytes (TILs) and blood regulatory T lymphocyte (Tregs, CD4+/CD25+/FoxP3+) expression in bladder cancer patients. The number of CD4+, CD8+, CD25+, FoxP3+ and CD20+ TILs was analyzed in association with clinico-pathomorphological features. In more advanced metastasizing tumors, showing non-classic differentiation (ND) and a more aggressive tissue invasion type (TIT), the number of TILs decreased. A low number of CD4+ TILs was associated with poor prognosis. Similarly, Treg frequency before surgery and after surgical treatment was significantly lower in more advanced tumors. The changes in TILs, as well as of local and systemic Tregs, were accompanied by changes in the histological phenotype of urothelial carcinoma regarding pT stage, NDs, TIT, and clinical outcomes. The number of TILs and the frequency of blood Tregs (indicators of antitumor response) may be essential for choosing an immunotherapy that is adjusted to the immune status according to the phase of tumor growth. Moreover, a significant reduction in the number of CD4+ and CD8+ TILs with the development of NDs in more advanced tumors may be associated with lower tumor immunogenicity, resulting in immune tolerance towards tumor tissue. These observations and the tendency of urothelial bladder carcinoma to undergo NDs in a heterogeneous manner during tumor progression suggest complex interactions between bladder cancer immunogenicity and stages of tumor progression. |
format | Online Article Text |
id | pubmed-4813149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-48131492016-04-06 Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study Jóźwicki, Wojciech Brożyna, Anna A. Siekiera, Jerzy Slominski, Andrzej T. Int J Mol Sci Article In the present study, we evaluated tumor-infiltrating lymphocytes (TILs) and blood regulatory T lymphocyte (Tregs, CD4+/CD25+/FoxP3+) expression in bladder cancer patients. The number of CD4+, CD8+, CD25+, FoxP3+ and CD20+ TILs was analyzed in association with clinico-pathomorphological features. In more advanced metastasizing tumors, showing non-classic differentiation (ND) and a more aggressive tissue invasion type (TIT), the number of TILs decreased. A low number of CD4+ TILs was associated with poor prognosis. Similarly, Treg frequency before surgery and after surgical treatment was significantly lower in more advanced tumors. The changes in TILs, as well as of local and systemic Tregs, were accompanied by changes in the histological phenotype of urothelial carcinoma regarding pT stage, NDs, TIT, and clinical outcomes. The number of TILs and the frequency of blood Tregs (indicators of antitumor response) may be essential for choosing an immunotherapy that is adjusted to the immune status according to the phase of tumor growth. Moreover, a significant reduction in the number of CD4+ and CD8+ TILs with the development of NDs in more advanced tumors may be associated with lower tumor immunogenicity, resulting in immune tolerance towards tumor tissue. These observations and the tendency of urothelial bladder carcinoma to undergo NDs in a heterogeneous manner during tumor progression suggest complex interactions between bladder cancer immunogenicity and stages of tumor progression. MDPI 2016-02-25 /pmc/articles/PMC4813149/ /pubmed/26927070 http://dx.doi.org/10.3390/ijms17030285 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jóźwicki, Wojciech Brożyna, Anna A. Siekiera, Jerzy Slominski, Andrzej T. Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study |
title | Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study |
title_full | Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study |
title_fullStr | Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study |
title_full_unstemmed | Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study |
title_short | Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study |
title_sort | changes in immunogenicity during the development of urinary bladder cancer: a preliminary study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813149/ https://www.ncbi.nlm.nih.gov/pubmed/26927070 http://dx.doi.org/10.3390/ijms17030285 |
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