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Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study

In the present study, we evaluated tumor-infiltrating lymphocytes (TILs) and blood regulatory T lymphocyte (Tregs, CD4+/CD25+/FoxP3+) expression in bladder cancer patients. The number of CD4+, CD8+, CD25+, FoxP3+ and CD20+ TILs was analyzed in association with clinico-pathomorphological features. In...

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Autores principales: Jóźwicki, Wojciech, Brożyna, Anna A., Siekiera, Jerzy, Slominski, Andrzej T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813149/
https://www.ncbi.nlm.nih.gov/pubmed/26927070
http://dx.doi.org/10.3390/ijms17030285
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author Jóźwicki, Wojciech
Brożyna, Anna A.
Siekiera, Jerzy
Slominski, Andrzej T.
author_facet Jóźwicki, Wojciech
Brożyna, Anna A.
Siekiera, Jerzy
Slominski, Andrzej T.
author_sort Jóźwicki, Wojciech
collection PubMed
description In the present study, we evaluated tumor-infiltrating lymphocytes (TILs) and blood regulatory T lymphocyte (Tregs, CD4+/CD25+/FoxP3+) expression in bladder cancer patients. The number of CD4+, CD8+, CD25+, FoxP3+ and CD20+ TILs was analyzed in association with clinico-pathomorphological features. In more advanced metastasizing tumors, showing non-classic differentiation (ND) and a more aggressive tissue invasion type (TIT), the number of TILs decreased. A low number of CD4+ TILs was associated with poor prognosis. Similarly, Treg frequency before surgery and after surgical treatment was significantly lower in more advanced tumors. The changes in TILs, as well as of local and systemic Tregs, were accompanied by changes in the histological phenotype of urothelial carcinoma regarding pT stage, NDs, TIT, and clinical outcomes. The number of TILs and the frequency of blood Tregs (indicators of antitumor response) may be essential for choosing an immunotherapy that is adjusted to the immune status according to the phase of tumor growth. Moreover, a significant reduction in the number of CD4+ and CD8+ TILs with the development of NDs in more advanced tumors may be associated with lower tumor immunogenicity, resulting in immune tolerance towards tumor tissue. These observations and the tendency of urothelial bladder carcinoma to undergo NDs in a heterogeneous manner during tumor progression suggest complex interactions between bladder cancer immunogenicity and stages of tumor progression.
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spelling pubmed-48131492016-04-06 Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study Jóźwicki, Wojciech Brożyna, Anna A. Siekiera, Jerzy Slominski, Andrzej T. Int J Mol Sci Article In the present study, we evaluated tumor-infiltrating lymphocytes (TILs) and blood regulatory T lymphocyte (Tregs, CD4+/CD25+/FoxP3+) expression in bladder cancer patients. The number of CD4+, CD8+, CD25+, FoxP3+ and CD20+ TILs was analyzed in association with clinico-pathomorphological features. In more advanced metastasizing tumors, showing non-classic differentiation (ND) and a more aggressive tissue invasion type (TIT), the number of TILs decreased. A low number of CD4+ TILs was associated with poor prognosis. Similarly, Treg frequency before surgery and after surgical treatment was significantly lower in more advanced tumors. The changes in TILs, as well as of local and systemic Tregs, were accompanied by changes in the histological phenotype of urothelial carcinoma regarding pT stage, NDs, TIT, and clinical outcomes. The number of TILs and the frequency of blood Tregs (indicators of antitumor response) may be essential for choosing an immunotherapy that is adjusted to the immune status according to the phase of tumor growth. Moreover, a significant reduction in the number of CD4+ and CD8+ TILs with the development of NDs in more advanced tumors may be associated with lower tumor immunogenicity, resulting in immune tolerance towards tumor tissue. These observations and the tendency of urothelial bladder carcinoma to undergo NDs in a heterogeneous manner during tumor progression suggest complex interactions between bladder cancer immunogenicity and stages of tumor progression. MDPI 2016-02-25 /pmc/articles/PMC4813149/ /pubmed/26927070 http://dx.doi.org/10.3390/ijms17030285 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jóźwicki, Wojciech
Brożyna, Anna A.
Siekiera, Jerzy
Slominski, Andrzej T.
Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study
title Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study
title_full Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study
title_fullStr Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study
title_full_unstemmed Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study
title_short Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study
title_sort changes in immunogenicity during the development of urinary bladder cancer: a preliminary study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813149/
https://www.ncbi.nlm.nih.gov/pubmed/26927070
http://dx.doi.org/10.3390/ijms17030285
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