Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics

Gut microbiota are intricately involved in the development of obesity-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and insulin resistance. In the current review, we discuss the role of gut microbiota in the development of NAFLD by focusing on the mech...

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Detalles Bibliográficos
Autores principales: He, Xuyun, Ji, Guang, Jia, Wei, Li, Houkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813164/
https://www.ncbi.nlm.nih.gov/pubmed/26999104
http://dx.doi.org/10.3390/ijms17030300
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author He, Xuyun
Ji, Guang
Jia, Wei
Li, Houkai
author_facet He, Xuyun
Ji, Guang
Jia, Wei
Li, Houkai
author_sort He, Xuyun
collection PubMed
description Gut microbiota are intricately involved in the development of obesity-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and insulin resistance. In the current review, we discuss the role of gut microbiota in the development of NAFLD by focusing on the mechanisms of gut microbiota-mediated host energy metabolism, insulin resistance, regulation of bile acids and choline metabolism, as well as gut microbiota-targeted therapy. We also discuss the application of a metabolomic approach to characterize gut microbial metabotypes in NAFLD.
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spelling pubmed-48131642016-04-06 Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics He, Xuyun Ji, Guang Jia, Wei Li, Houkai Int J Mol Sci Review Gut microbiota are intricately involved in the development of obesity-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and insulin resistance. In the current review, we discuss the role of gut microbiota in the development of NAFLD by focusing on the mechanisms of gut microbiota-mediated host energy metabolism, insulin resistance, regulation of bile acids and choline metabolism, as well as gut microbiota-targeted therapy. We also discuss the application of a metabolomic approach to characterize gut microbial metabotypes in NAFLD. MDPI 2016-03-15 /pmc/articles/PMC4813164/ /pubmed/26999104 http://dx.doi.org/10.3390/ijms17030300 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
He, Xuyun
Ji, Guang
Jia, Wei
Li, Houkai
Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics
title Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics
title_full Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics
title_fullStr Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics
title_full_unstemmed Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics
title_short Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics
title_sort gut microbiota and nonalcoholic fatty liver disease: insights on mechanism and application of metabolomics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813164/
https://www.ncbi.nlm.nih.gov/pubmed/26999104
http://dx.doi.org/10.3390/ijms17030300
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