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Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases

Pyruvate dehydrogenase kinases (PDKs) are key enzymes in glucose metabolism, negatively regulating pyruvate dehyrogenase complex (PDC) activity through phosphorylation. Inhibiting PDKs could upregulate PDC activity and drive cells into more aerobic metabolism. Therefore, PDKs are potential targets f...

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Detalles Bibliográficos
Autores principales:	Zhou, Xiaoli, Yu, Shanshan, Su, Jing, Sun, Liankun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813202/ https://www.ncbi.nlm.nih.gov/pubmed/26959013 http://dx.doi.org/10.3390/ijms17030340

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