Cargando…

Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology

Deregulation of the cholesterol pathway is an anomaly observed in human diseases, many of which have in common neurological involvement and unknown pathogenesis. In this study we have used Mevalonate Kinase Deficiency (MKD) as a disease-model in order to investigate the link between the deregulation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marcuzzi, Annalisa, Piscianz, Elisa, Zweyer, Marina, Bortul, Roberta, Loganes, Claudia, Girardelli, Martina, Baj, Gabriele, Monasta, Lorenzo, Celeghini, Claudio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813225/ https://www.ncbi.nlm.nih.gov/pubmed/26978350 http://dx.doi.org/10.3390/ijms17030365

Ejemplares similares

Neuronal Dysfunction Associated with Cholesterol Deregulation
por: Marcuzzi, Annalisa, et al.
Publicado: (2018)

Innovative Target Therapies Are Able to Block the Inflammation Associated with Dysfunction of the Cholesterol Biosynthesis Pathway
por: Marcuzzi, Annalisa, et al.
Publicado: (2015)

MitoQ Is Able to Modulate Apoptosis and Inflammation
por: Piscianz, Elisa, et al.
Publicado: (2021)

Mevalonate Kinase Deficiency and Neuroinflammation: Balance between Apoptosis and Pyroptosis
por: Tricarico, Paola Maura, et al.
Publicado: (2013)

To Extinguish the Fire from Outside the Cell or to Shutdown the Gas Valve Inside? Novel Trends in Anti-Inflammatory Therapies
por: Marcuzzi, Annalisa, et al.
Publicado: (2015)

Genetic and Functional Profiling of Crohn's Disease: Autophagy Mechanism and Susceptibility to Infectious Diseases
por: Marcuzzi, Annalisa, et al.
Publicado: (2013)

Clinical Genetic Testing of Periodic Fever Syndromes
por: Marcuzzi, Annalisa, et al.
Publicado: (2013)

Temperature and Drug Treatments in Mevalonate Kinase Deficiency: An Ex Vivo Study
por: Tricarico, Paola Maura, et al.
Publicado: (2013)

Altered pattern of tumor necrosis factor-alpha production in peripheral blood monocytes from Crohn's disease
por: Loganes, Claudia, et al.
Publicado: (2016)

Curcumin Anti-Apoptotic Action in a Model of Intestinal Epithelial Inflammatory Damage
por: Loganes, Claudia, et al.
Publicado: (2017)

Lovastatin Dose-Dependently Potentiates the Pro-inflammatory Activity of Lipopolysaccharide Both In Vitro and In Vivo
por: Zanin, Valentina, et al.
Publicado: (2013)

Levels of circulating TNF-related apoptosis-inducing ligand in celiac disease
por: CELEGHINI, CLAUDIO, et al.
Publicado: (2014)

Ex vivo response to mucosal bacteria and muramyl dipeptide in inflammatory bowel disease
por: Loganes, Claudia, et al.
Publicado: (2016)

Is autophagy an elective strategy to protect neurons from dysregulated cholesterol metabolism?
por: Piscianz, Elisa, et al.
Publicado: (2019)

The Complex Interplay between Lipids, Immune System and Interleukins in Cardio-Metabolic Diseases
por: Bernardi, Stella, et al.
Publicado: (2018)

Engineering Saccharomyces cerevisiae for geranylgeraniol overproduction by combinatorial design
por: Song, Tian-Qing, et al.
Publicado: (2017)

The Role of Geranylgeraniol in Managing Bisphosphonate-Related Osteonecrosis of the Jaw
por: Chin, Kok-Yong, et al.
Publicado: (2022)

The Biomedical Importance of the Missing Pathway for Farnesol and Geranylgeraniol Salvage
por: Verdaguer, Ignasi Bofill, et al.
Publicado: (2022)

Cytokine Levels in the Serum of Healthy Subjects
por: Kleiner, Giulio, et al.
Publicado: (2013)

Geranylgeraniol Application in Human Osteoblasts and Osteoclasts for Reversal of the Effect of Bisphosphonates
por: Jung, Junho, et al.
Publicado: (2023)

Lovastatin induces apoptosis through the mitochondrial pathway in an undifferentiated SH-SY5Y neuroblastoma cell line
por: Marcuzzi, A, et al.
Publicado: (2013)

Mevalonate kinase deficiency and IBD: shared genetic background
por: Bianco, Anna Monica, et al.
Publicado: (2014)

Mitochondria-Targeted Antioxidants, an Innovative Class of Antioxidant Compounds for Neurodegenerative Diseases: Perspectives and Limitations
por: Fields, Matteo, et al.
Publicado: (2023)

An Easy and Reliable Strategy for Making Type I Interferon Signature Analysis Comparable among Research Centers
por: Pin, Alessia, et al.
Publicado: (2019)

Inhibition of mesenchymal stromal cells by pre-activated lymphocytes and their culture media
por: Valencic, Erica, et al.
Publicado: (2014)

Alendronate, a double-edged sword acting in the mevalonate pathway
por: TRICARICO, PAOLA MAURA, et al.
Publicado: (2015)

Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments
por: Vecchi Brumatti, Liza, et al.
Publicado: (2014)

Mitochondria Superoxide Anion Production Contributes to Geranylgeraniol-Induced Death in Leishmania amazonensis
por: Lopes, Milene Valéria, et al.
Publicado: (2012)

The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase
por: Schumacher, Marc M, et al.
Publicado: (2015)

In vitro Effect of Geranylgeraniol (GGOH) on Bisphosphonate-Induced Cytotoxicity of Oral Mucosa Cells
por: Rattanawonsakul, Krit, et al.
Publicado: (2022)

Inflammatory bowel disease and patterns of volatile organic compounds in the exhaled breath of children: A case-control study using Ion Molecule Reaction-Mass Spectrometry
por: Monasta, Lorenzo, et al.
Publicado: (2017)

Block of the Mevalonate Pathway Triggers Oxidative and Inflammatory Molecular Mechanisms Modulated by Exogenous Isoprenoid Compounds
por: Tricarico, Paola Maura, et al.
Publicado: (2014)

Geranylgeraniol Restores Zoledronic Acid-Induced Efferocytosis Inhibition in Bisphosphonate-Related Osteonecrosis of the Jaw
por: Chen, Xin, et al.
Publicado: (2021)

Dietary Geranylgeraniol and Statins May Act Synergistically to Mitigate Oxidative Stress in Obese Mice
por: Meister, Maureen, et al.
Publicado: (2022)

The diagnostic challenge of very early-onset enterocolitis in an infant with XIAP deficiency
por: Girardelli, Martina, et al.
Publicado: (2015)

Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer
por: de Wolf, Elizabeth, et al.
Publicado: (2017)

Potential role of geranylgeraniol in managing statin-associated muscle symptoms: a COVID-19 related perspective
por: Tan, Barrie, et al.
Publicado: (2023)

Monocyte‐predominant engraftment, cytokine levels and early transplant‐related complications in pediatric hematopoietic stem cell recipients
por: Maximova, Natalia, et al.
Publicado: (2019)

Geranylgeraniol (GGOH) as a Mevalonate Pathway Activator in the Rescue of Bone Cells Treated with Zoledronic Acid: An In Vitro Study
por: Fliefel, Riham M., et al.
Publicado: (2019)

Immunity and Genetics at the Revolving Doors of Diagnostics in Primary Immunodeficiencies
por: Rispoli, Francesco, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_fdd842hockdm6m3cv8gvg6t0pr