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Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer

Herein, we present a study focused on the determination of the influence of long-distance (53 km) bicycle riding on levels of chosen biochemical urinary and serum prostate cancer (PCa) biomarkers total prostate-specific antigen (tPSA), free PSA (fPSA) and sarcosine. Fourteen healthy participants wit...

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Autores principales: Heger, Zbynek, Gumulec, Jaromir, Ondrak, Ales, Skoda, Jan, Zitka, Zdenek, Cernei, Natalia, Masarik, Michal, Zitka, Ondrej, Adam, Vojtech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813236/
https://www.ncbi.nlm.nih.gov/pubmed/26999116
http://dx.doi.org/10.3390/ijms17030377
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author Heger, Zbynek
Gumulec, Jaromir
Ondrak, Ales
Skoda, Jan
Zitka, Zdenek
Cernei, Natalia
Masarik, Michal
Zitka, Ondrej
Adam, Vojtech
author_facet Heger, Zbynek
Gumulec, Jaromir
Ondrak, Ales
Skoda, Jan
Zitka, Zdenek
Cernei, Natalia
Masarik, Michal
Zitka, Ondrej
Adam, Vojtech
author_sort Heger, Zbynek
collection PubMed
description Herein, we present a study focused on the determination of the influence of long-distance (53 km) bicycle riding on levels of chosen biochemical urinary and serum prostate cancer (PCa) biomarkers total prostate-specific antigen (tPSA), free PSA (fPSA) and sarcosine. Fourteen healthy participants with no evidence of prostate diseases, in the age range from 49–57 years with a median of 52 years, underwent physical exercise (mean race time of 150 ± 20 min, elevation increase of 472 m) and pre- and post-ride blood/urine sampling. It was found that bicycle riding resulted in elevated serum uric acid (p = 0.001, median 271.76 vs. 308.44 µmol/L pre- and post-ride, respectively), lactate (p = 0.01, median 2.98 vs. 4.8 mmol/L) and C-reactive protein (p = 0.01, 0.0–0.01 mg/L). It is noteworthy that our work supports the studies demonstrating an increased PSA after mechanical manipulation of the prostate. The subjects exhibited either significantly higher post-ride tPSA (p = 0.002, median 0.69 vs. 1.1 ng/mL pre- and post-ride, respectively) and fPSA (p = 0.028, median 0.25 vs. 0.35 ng/mL). Contrary to that, sarcosine levels were not significantly affected by physical exercise (p = 0.20, median 1.64 vs. 1.92 µmol/mL for serum sarcosine, and p = 0.15, median 0.02 µmol/mmol of creatinine vs. 0.01 µmol/mmol of creatinine for urinary sarcosine). Taken together, our pilot study provides the first evidence that the potential biomarker of PCa—sarcosine does not have a drawback by means of a bicycle riding-induced false positivity, as was shown in the case of PSA.
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spelling pubmed-48132362016-04-06 Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer Heger, Zbynek Gumulec, Jaromir Ondrak, Ales Skoda, Jan Zitka, Zdenek Cernei, Natalia Masarik, Michal Zitka, Ondrej Adam, Vojtech Int J Mol Sci Article Herein, we present a study focused on the determination of the influence of long-distance (53 km) bicycle riding on levels of chosen biochemical urinary and serum prostate cancer (PCa) biomarkers total prostate-specific antigen (tPSA), free PSA (fPSA) and sarcosine. Fourteen healthy participants with no evidence of prostate diseases, in the age range from 49–57 years with a median of 52 years, underwent physical exercise (mean race time of 150 ± 20 min, elevation increase of 472 m) and pre- and post-ride blood/urine sampling. It was found that bicycle riding resulted in elevated serum uric acid (p = 0.001, median 271.76 vs. 308.44 µmol/L pre- and post-ride, respectively), lactate (p = 0.01, median 2.98 vs. 4.8 mmol/L) and C-reactive protein (p = 0.01, 0.0–0.01 mg/L). It is noteworthy that our work supports the studies demonstrating an increased PSA after mechanical manipulation of the prostate. The subjects exhibited either significantly higher post-ride tPSA (p = 0.002, median 0.69 vs. 1.1 ng/mL pre- and post-ride, respectively) and fPSA (p = 0.028, median 0.25 vs. 0.35 ng/mL). Contrary to that, sarcosine levels were not significantly affected by physical exercise (p = 0.20, median 1.64 vs. 1.92 µmol/mL for serum sarcosine, and p = 0.15, median 0.02 µmol/mmol of creatinine vs. 0.01 µmol/mmol of creatinine for urinary sarcosine). Taken together, our pilot study provides the first evidence that the potential biomarker of PCa—sarcosine does not have a drawback by means of a bicycle riding-induced false positivity, as was shown in the case of PSA. MDPI 2016-03-17 /pmc/articles/PMC4813236/ /pubmed/26999116 http://dx.doi.org/10.3390/ijms17030377 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Heger, Zbynek
Gumulec, Jaromir
Ondrak, Ales
Skoda, Jan
Zitka, Zdenek
Cernei, Natalia
Masarik, Michal
Zitka, Ondrej
Adam, Vojtech
Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer
title Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer
title_full Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer
title_fullStr Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer
title_full_unstemmed Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer
title_short Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer
title_sort influence of long-distance bicycle riding on serum/urinary biomarkers of prostate cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813236/
https://www.ncbi.nlm.nih.gov/pubmed/26999116
http://dx.doi.org/10.3390/ijms17030377
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