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Spatial Temporal Dynamics and Molecular Evolution of Re-Emerging Rabies Virus in Taiwan

Taiwan has been recognized by the World Organization for Animal Health as rabies-free since 1961. Surprisingly, rabies virus (RABV) was identified in a dead Formosan ferret badger in July 2013. Later, more infected ferret badgers were reported from different geographic regions of Taiwan. In order to...

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Autores principales: Lin, Yung-Cheng, Chu, Pei-Yu, Chang, Mei-Yin, Hsiao, Kuang-Liang, Lin, Jih-Hui, Liu, Hsin-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813248/
https://www.ncbi.nlm.nih.gov/pubmed/26999115
http://dx.doi.org/10.3390/ijms17030392
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author Lin, Yung-Cheng
Chu, Pei-Yu
Chang, Mei-Yin
Hsiao, Kuang-Liang
Lin, Jih-Hui
Liu, Hsin-Fu
author_facet Lin, Yung-Cheng
Chu, Pei-Yu
Chang, Mei-Yin
Hsiao, Kuang-Liang
Lin, Jih-Hui
Liu, Hsin-Fu
author_sort Lin, Yung-Cheng
collection PubMed
description Taiwan has been recognized by the World Organization for Animal Health as rabies-free since 1961. Surprisingly, rabies virus (RABV) was identified in a dead Formosan ferret badger in July 2013. Later, more infected ferret badgers were reported from different geographic regions of Taiwan. In order to know its evolutionary history and spatial temporal dynamics of this virus, phylogeny was reconstructed by maximum likelihood and Bayesian methods based on the full-length of glycoprotein (G), matrix protein (M), and nucleoprotein (N) genes. The evolutionary rates and phylogeographic were determined using Beast and SPREAD software. Phylogenetic trees showed a monophyletic group containing all of RABV isolates from Taiwan and it further separated into three sub-groups. The estimated nucleotide substitution rates of G, M, and N genes were between 2.49 × 10(−4)–4.75 × 10(−4) substitutions/site/year, and the mean ratio of dN/dS was significantly low. The time of the most recent common ancestor was estimated around 75, 89, and 170 years, respectively. Phylogeographic analysis suggested the origin of the epidemic could be in Eastern Taiwan, then the Formosan ferret badger moved across the Central Range of Taiwan to western regions and separated into two branches. In this study, we illustrated the evolution history and phylogeographic of RABV in Formosan ferret badgers.
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spelling pubmed-48132482016-04-06 Spatial Temporal Dynamics and Molecular Evolution of Re-Emerging Rabies Virus in Taiwan Lin, Yung-Cheng Chu, Pei-Yu Chang, Mei-Yin Hsiao, Kuang-Liang Lin, Jih-Hui Liu, Hsin-Fu Int J Mol Sci Article Taiwan has been recognized by the World Organization for Animal Health as rabies-free since 1961. Surprisingly, rabies virus (RABV) was identified in a dead Formosan ferret badger in July 2013. Later, more infected ferret badgers were reported from different geographic regions of Taiwan. In order to know its evolutionary history and spatial temporal dynamics of this virus, phylogeny was reconstructed by maximum likelihood and Bayesian methods based on the full-length of glycoprotein (G), matrix protein (M), and nucleoprotein (N) genes. The evolutionary rates and phylogeographic were determined using Beast and SPREAD software. Phylogenetic trees showed a monophyletic group containing all of RABV isolates from Taiwan and it further separated into three sub-groups. The estimated nucleotide substitution rates of G, M, and N genes were between 2.49 × 10(−4)–4.75 × 10(−4) substitutions/site/year, and the mean ratio of dN/dS was significantly low. The time of the most recent common ancestor was estimated around 75, 89, and 170 years, respectively. Phylogeographic analysis suggested the origin of the epidemic could be in Eastern Taiwan, then the Formosan ferret badger moved across the Central Range of Taiwan to western regions and separated into two branches. In this study, we illustrated the evolution history and phylogeographic of RABV in Formosan ferret badgers. MDPI 2016-03-17 /pmc/articles/PMC4813248/ /pubmed/26999115 http://dx.doi.org/10.3390/ijms17030392 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Yung-Cheng
Chu, Pei-Yu
Chang, Mei-Yin
Hsiao, Kuang-Liang
Lin, Jih-Hui
Liu, Hsin-Fu
Spatial Temporal Dynamics and Molecular Evolution of Re-Emerging Rabies Virus in Taiwan
title Spatial Temporal Dynamics and Molecular Evolution of Re-Emerging Rabies Virus in Taiwan
title_full Spatial Temporal Dynamics and Molecular Evolution of Re-Emerging Rabies Virus in Taiwan
title_fullStr Spatial Temporal Dynamics and Molecular Evolution of Re-Emerging Rabies Virus in Taiwan
title_full_unstemmed Spatial Temporal Dynamics and Molecular Evolution of Re-Emerging Rabies Virus in Taiwan
title_short Spatial Temporal Dynamics and Molecular Evolution of Re-Emerging Rabies Virus in Taiwan
title_sort spatial temporal dynamics and molecular evolution of re-emerging rabies virus in taiwan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813248/
https://www.ncbi.nlm.nih.gov/pubmed/26999115
http://dx.doi.org/10.3390/ijms17030392
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