A Review of Ribonuclease 7’s Structure, Regulation, and Contributions to Host Defense

The Ribonuclease A Superfamily is composed of a group of structurally similar peptides that are secreted by immune cells and epithelial tissues. Several members of the Ribonuclease A Superfamily demonstrate antimicrobial activity, and it has been suggested that some of these ribonucleases play an es...

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Detalles Bibliográficos
Autores principales: Becknell, Brian, Spencer, John David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813274/
https://www.ncbi.nlm.nih.gov/pubmed/27011175
http://dx.doi.org/10.3390/ijms17030423
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author Becknell, Brian
Spencer, John David
author_facet Becknell, Brian
Spencer, John David
author_sort Becknell, Brian
collection PubMed
description The Ribonuclease A Superfamily is composed of a group of structurally similar peptides that are secreted by immune cells and epithelial tissues. Several members of the Ribonuclease A Superfamily demonstrate antimicrobial activity, and it has been suggested that some of these ribonucleases play an essential role in host defense. Ribonuclease 7 (RNase 7) is an epithelial-derived secreted peptide with potent broad-spectrum antimicrobial activity. This review summarizes the published literature on RNase 7’s antimicrobial properties, structure, regulation, and contributions to host defense. In doing so, we conclude by highlighting key knowledge gaps that must be investigated to completely understand the potential of developing RNase 7 as a novel therapeutic for human infectious diseases.
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spelling pubmed-48132742016-04-06 A Review of Ribonuclease 7’s Structure, Regulation, and Contributions to Host Defense Becknell, Brian Spencer, John David Int J Mol Sci Review The Ribonuclease A Superfamily is composed of a group of structurally similar peptides that are secreted by immune cells and epithelial tissues. Several members of the Ribonuclease A Superfamily demonstrate antimicrobial activity, and it has been suggested that some of these ribonucleases play an essential role in host defense. Ribonuclease 7 (RNase 7) is an epithelial-derived secreted peptide with potent broad-spectrum antimicrobial activity. This review summarizes the published literature on RNase 7’s antimicrobial properties, structure, regulation, and contributions to host defense. In doing so, we conclude by highlighting key knowledge gaps that must be investigated to completely understand the potential of developing RNase 7 as a novel therapeutic for human infectious diseases. MDPI 2016-03-22 /pmc/articles/PMC4813274/ /pubmed/27011175 http://dx.doi.org/10.3390/ijms17030423 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Becknell, Brian
Spencer, John David
A Review of Ribonuclease 7’s Structure, Regulation, and Contributions to Host Defense
title A Review of Ribonuclease 7’s Structure, Regulation, and Contributions to Host Defense
title_full A Review of Ribonuclease 7’s Structure, Regulation, and Contributions to Host Defense
title_fullStr A Review of Ribonuclease 7’s Structure, Regulation, and Contributions to Host Defense
title_full_unstemmed A Review of Ribonuclease 7’s Structure, Regulation, and Contributions to Host Defense
title_short A Review of Ribonuclease 7’s Structure, Regulation, and Contributions to Host Defense
title_sort review of ribonuclease 7’s structure, regulation, and contributions to host defense
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813274/
https://www.ncbi.nlm.nih.gov/pubmed/27011175
http://dx.doi.org/10.3390/ijms17030423
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