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Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer
Gastric cancer is the third leading cause of cancer mortality worldwide. Unfortunately, most gastric cancer cases are diagnosed in an advanced, non-curable stage and with a limited response to chemotherapy. Drug resistance is one of the most important causes of therapy failure in gastric cancer pati...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813275/ https://www.ncbi.nlm.nih.gov/pubmed/27011182 http://dx.doi.org/10.3390/ijms17030424 |
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author | Riquelme, Ismael Letelier, Pablo Riffo-Campos, Angela L. Brebi, Priscilla Roa, Juan Carlos |
author_facet | Riquelme, Ismael Letelier, Pablo Riffo-Campos, Angela L. Brebi, Priscilla Roa, Juan Carlos |
author_sort | Riquelme, Ismael |
collection | PubMed |
description | Gastric cancer is the third leading cause of cancer mortality worldwide. Unfortunately, most gastric cancer cases are diagnosed in an advanced, non-curable stage and with a limited response to chemotherapy. Drug resistance is one of the most important causes of therapy failure in gastric cancer patients. Although the mechanisms of drug resistance have been broadly studied, the regulation of these mechanisms has not been completely understood. Accumulating evidence has recently highlighted the role of microRNAs in the development and maintenance of drug resistance due to their regulatory features in specific genes involved in the chemoresistant phenotype of malignancies, including gastric cancer. This review summarizes the current knowledge about the miRNAs’ characteristics, their regulation of the genes involved in chemoresistance and their potential as targeted therapies for personalized treatment in resistant gastric cancer. |
format | Online Article Text |
id | pubmed-4813275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-48132752016-04-06 Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer Riquelme, Ismael Letelier, Pablo Riffo-Campos, Angela L. Brebi, Priscilla Roa, Juan Carlos Int J Mol Sci Review Gastric cancer is the third leading cause of cancer mortality worldwide. Unfortunately, most gastric cancer cases are diagnosed in an advanced, non-curable stage and with a limited response to chemotherapy. Drug resistance is one of the most important causes of therapy failure in gastric cancer patients. Although the mechanisms of drug resistance have been broadly studied, the regulation of these mechanisms has not been completely understood. Accumulating evidence has recently highlighted the role of microRNAs in the development and maintenance of drug resistance due to their regulatory features in specific genes involved in the chemoresistant phenotype of malignancies, including gastric cancer. This review summarizes the current knowledge about the miRNAs’ characteristics, their regulation of the genes involved in chemoresistance and their potential as targeted therapies for personalized treatment in resistant gastric cancer. MDPI 2016-03-22 /pmc/articles/PMC4813275/ /pubmed/27011182 http://dx.doi.org/10.3390/ijms17030424 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Riquelme, Ismael Letelier, Pablo Riffo-Campos, Angela L. Brebi, Priscilla Roa, Juan Carlos Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer |
title | Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer |
title_full | Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer |
title_fullStr | Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer |
title_full_unstemmed | Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer |
title_short | Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer |
title_sort | emerging role of mirnas in the drug resistance of gastric cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813275/ https://www.ncbi.nlm.nih.gov/pubmed/27011182 http://dx.doi.org/10.3390/ijms17030424 |
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