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Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis

The mitochondrial permeability transition pore is a recognized drug target for neurodegenerative conditions such as multiple sclerosis and for ischemia-reperfusion injury in the brain and heart. The peptidylprolyl isomerase, cyclophilin D (CypD, PPIF), is a positive regulator of the pore, and geneti...

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Detalles Bibliográficos
Autores principales:	Warne, Justin, Pryce, Gareth, Hill, Julia M., Shi, Xiao, Lennerås, Felicia, Puentes, Fabiola, Kip, Maarten, Hilditch, Laura, Walker, Paul, Simone, Michela I., Chan, A. W. Edith, Towers, Greg J., Coker, Alun R., Duchen, Michael R., Szabadkai, Gyorgy, Baker, David, Selwood, David L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813465/ https://www.ncbi.nlm.nih.gov/pubmed/26679998 http://dx.doi.org/10.1074/jbc.M115.700385

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