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β-Subunit Binding Is Sufficient for Ligands to Open the Integrin α(IIb)β(3) Headpiece

The platelet integrin α(IIb)β(3) binds to a KQAGDV motif at the fibrinogen γ-chain C terminus and to RGD motifs present in loops in many extracellular matrix proteins. These ligands bind in a groove between the integrin α and β-subunits; the basic Lys or Arg side chain hydrogen bonds to the α(IIb)-s...

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Detalles Bibliográficos
Autores principales:	Lin, Fu-Yang, Zhu, Jianghai, Eng, Edward T., Hudson, Nathan E., Springer, Timothy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Membrane Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813479/ https://www.ncbi.nlm.nih.gov/pubmed/26631735 http://dx.doi.org/10.1074/jbc.M115.705624

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