Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects

Omenn syndrome (OS) is caused by hypomorphic Rag mutations and characterized by a profound immunodeficiency associated with autoimmune-like manifestations. Both in humans and mice, OS is mediated by oligoclonal activated T and B cells. The role of microbial signals in disease pathogenesis is debated...

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Detalles Bibliográficos
Autores principales: Rigoni, Rosita, Fontana, Elena, Guglielmetti, Simone, Fosso, Bruno, D’Erchia, Anna Maria, Maina, Virginia, Taverniti, Valentina, Castiello, Maria Carmina, Mantero, Stefano, Pacchiana, Giovanni, Musio, Silvia, Pedotti, Rosetta, Selmi, Carlo, Mora, J. Rodrigo, Pesole, Graziano, Vezzoni, Paolo, Poliani, Pietro Luigi, Grassi, Fabio, Villa, Anna, Cassani, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813669/
https://www.ncbi.nlm.nih.gov/pubmed/26926994
http://dx.doi.org/10.1084/jem.20151116

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