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Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station

Adaptation to the space environment can sometimes pose physiological problems to International Space Station (ISS) astronauts after their return to earth. Therefore, it is important to develop healthcare technologies for astronauts. In this study, we examined the feasibility of using hair follicles,...

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Autores principales: Terada, Masahiro, Seki, Masaya, Takahashi, Rika, Yamada, Shin, Higashibata, Akira, Majima, Hideyuki J., Sudoh, Masamichi, Mukai, Chiaki, Ishioka, Noriaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814050/
https://www.ncbi.nlm.nih.gov/pubmed/27029003
http://dx.doi.org/10.1371/journal.pone.0150801
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author Terada, Masahiro
Seki, Masaya
Takahashi, Rika
Yamada, Shin
Higashibata, Akira
Majima, Hideyuki J.
Sudoh, Masamichi
Mukai, Chiaki
Ishioka, Noriaki
author_facet Terada, Masahiro
Seki, Masaya
Takahashi, Rika
Yamada, Shin
Higashibata, Akira
Majima, Hideyuki J.
Sudoh, Masamichi
Mukai, Chiaki
Ishioka, Noriaki
author_sort Terada, Masahiro
collection PubMed
description Adaptation to the space environment can sometimes pose physiological problems to International Space Station (ISS) astronauts after their return to earth. Therefore, it is important to develop healthcare technologies for astronauts. In this study, we examined the feasibility of using hair follicles, a readily obtained sample, to assess gene expression changes in response to spaceflight adaptation. In order to investigate the gene expression changes in human hair follicles during spaceflight, hair follicles of 10 astronauts were analyzed by microarray and real time qPCR analyses. We found that spaceflight alters human hair follicle gene expression. The degree of changes in gene expression was found to vary among individuals. In some astronauts, genes related to hair growth such as FGF18, ANGPTL7 and COMP were upregulated during flight, suggesting that spaceflight inhibits cell proliferation in hair follicles.
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spelling pubmed-48140502016-04-05 Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station Terada, Masahiro Seki, Masaya Takahashi, Rika Yamada, Shin Higashibata, Akira Majima, Hideyuki J. Sudoh, Masamichi Mukai, Chiaki Ishioka, Noriaki PLoS One Research Article Adaptation to the space environment can sometimes pose physiological problems to International Space Station (ISS) astronauts after their return to earth. Therefore, it is important to develop healthcare technologies for astronauts. In this study, we examined the feasibility of using hair follicles, a readily obtained sample, to assess gene expression changes in response to spaceflight adaptation. In order to investigate the gene expression changes in human hair follicles during spaceflight, hair follicles of 10 astronauts were analyzed by microarray and real time qPCR analyses. We found that spaceflight alters human hair follicle gene expression. The degree of changes in gene expression was found to vary among individuals. In some astronauts, genes related to hair growth such as FGF18, ANGPTL7 and COMP were upregulated during flight, suggesting that spaceflight inhibits cell proliferation in hair follicles. Public Library of Science 2016-03-30 /pmc/articles/PMC4814050/ /pubmed/27029003 http://dx.doi.org/10.1371/journal.pone.0150801 Text en © 2016 Terada et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Terada, Masahiro
Seki, Masaya
Takahashi, Rika
Yamada, Shin
Higashibata, Akira
Majima, Hideyuki J.
Sudoh, Masamichi
Mukai, Chiaki
Ishioka, Noriaki
Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station
title Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station
title_full Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station
title_fullStr Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station
title_full_unstemmed Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station
title_short Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station
title_sort effects of a closed space environment on gene expression in hair follicles of astronauts in the international space station
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814050/
https://www.ncbi.nlm.nih.gov/pubmed/27029003
http://dx.doi.org/10.1371/journal.pone.0150801
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