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Elevated p16ink4a Expression in Human Labial Salivary Glands as a Potential Correlate of Cognitive Aging in Late Midlife

BACKGROUND: The cell-cycle inhibitor and tumor suppressor cyclin dependent kinase inhibitor, p16(ink4a), is one of the two gene products of the ink4a/ARF (cdkn2a) locus on chromosome 9q21. Up-regulation of p16(ink4a) has been linked to cellular senescence, and findings from studies on different mamm...

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Detalles Bibliográficos
Autores principales:	Sørensen, Christiane Elisabeth, Tritsaris, Katerina, Reibel, Jesper, Lauritzen, Martin, Mortensen, Erik Lykke, Osler, Merete, Pedersen, Anne Marie Lynge
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814104/ https://www.ncbi.nlm.nih.gov/pubmed/27029014 http://dx.doi.org/10.1371/journal.pone.0152612

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