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Design of Novel Relaxase Substrates Based on Rolling Circle Replicases for Bioconjugation to DNA Nanostructures

During bacterial conjugation and rolling circle replication, HUH endonucleases, respectively known as relaxases and replicases, form a covalent bond with ssDNA when they cleave their target sequence (nic site). Both protein families show structural similarity but limited amino acid identity. Moreove...

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Detalles Bibliográficos
Autores principales:	Sagredo, Sandra, de la Cruz, Fernando, Moncalián, Gabriel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814116/ https://www.ncbi.nlm.nih.gov/pubmed/27027740 http://dx.doi.org/10.1371/journal.pone.0152666

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