Establishment of a Therapeutic Anti-Pan HLA-Class II Monoclonal Antibody That Directly Induces Lymphoma Cell Death via Large Pore Formation

To develop a new therapeutic monoclonal Antibody (mAb) for Hodgkin lymphoma (HL), we immunized a BALB/c mouse with live HL cell lines, alternating between two HL cell lines. After hybridization, we screened the hybridoma clones by assessing direct cytotoxicity against a HL cell line not used for imm...

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Detalles Bibliográficos
Autores principales: Matsuoka, Shuji, Ishii, Yasuyuki, Nakao, Atsuhito, Abe, Masaaki, Ohtsuji, Naomi, Momose, Shuji, Jin, Hui, Arase, Hisashi, Sugimoto, Koichi, Nakauchi, Yusuke, Masutani, Hiroshi, Maeda, Michiyuki, Yagita, Hideo, Komatsu, Norio, Hino, Okio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814124/
https://www.ncbi.nlm.nih.gov/pubmed/27028595
http://dx.doi.org/10.1371/journal.pone.0150496

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