Myeloid-Derived Suppressor Cells in Bacterial Infections

Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious dise...

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Detalles Bibliográficos
Autores principales: Ost, Michael, Singh, Anurag, Peschel, Andreas, Mehling, Roman, Rieber, Nikolaus, Hartl, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814452/
https://www.ncbi.nlm.nih.gov/pubmed/27066459
http://dx.doi.org/10.3389/fcimb.2016.00037
Descripción
Sumario:Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics.

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