Myeloid-Derived Suppressor Cells in Bacterial Infections

Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious dise...

Descripción completa

Detalles Bibliográficos
Autores principales: Ost, Michael, Singh, Anurag, Peschel, Andreas, Mehling, Roman, Rieber, Nikolaus, Hartl, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814452/
https://www.ncbi.nlm.nih.gov/pubmed/27066459
http://dx.doi.org/10.3389/fcimb.2016.00037
_version_ 1782424411620507648
author Ost, Michael
Singh, Anurag
Peschel, Andreas
Mehling, Roman
Rieber, Nikolaus
Hartl, Dominik
author_facet Ost, Michael
Singh, Anurag
Peschel, Andreas
Mehling, Roman
Rieber, Nikolaus
Hartl, Dominik
author_sort Ost, Michael
collection PubMed
description Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics.
format Online
Article
Text
id pubmed-4814452
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-48144522016-04-08 Myeloid-Derived Suppressor Cells in Bacterial Infections Ost, Michael Singh, Anurag Peschel, Andreas Mehling, Roman Rieber, Nikolaus Hartl, Dominik Front Cell Infect Microbiol Microbiology Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics. Frontiers Media S.A. 2016-03-31 /pmc/articles/PMC4814452/ /pubmed/27066459 http://dx.doi.org/10.3389/fcimb.2016.00037 Text en Copyright © 2016 Ost, Singh, Peschel, Mehling, Rieber and Hartl. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Ost, Michael
Singh, Anurag
Peschel, Andreas
Mehling, Roman
Rieber, Nikolaus
Hartl, Dominik
Myeloid-Derived Suppressor Cells in Bacterial Infections
title Myeloid-Derived Suppressor Cells in Bacterial Infections
title_full Myeloid-Derived Suppressor Cells in Bacterial Infections
title_fullStr Myeloid-Derived Suppressor Cells in Bacterial Infections
title_full_unstemmed Myeloid-Derived Suppressor Cells in Bacterial Infections
title_short Myeloid-Derived Suppressor Cells in Bacterial Infections
title_sort myeloid-derived suppressor cells in bacterial infections
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814452/
https://www.ncbi.nlm.nih.gov/pubmed/27066459
http://dx.doi.org/10.3389/fcimb.2016.00037
work_keys_str_mv AT ostmichael myeloidderivedsuppressorcellsinbacterialinfections
AT singhanurag myeloidderivedsuppressorcellsinbacterialinfections
AT peschelandreas myeloidderivedsuppressorcellsinbacterialinfections
AT mehlingroman myeloidderivedsuppressorcellsinbacterialinfections
AT riebernikolaus myeloidderivedsuppressorcellsinbacterialinfections
AT hartldominik myeloidderivedsuppressorcellsinbacterialinfections

Ejemplares similares