Acetylation of C/EBPα inhibits its granulopoietic function

CCAAT/enhancer-binding protein alpha (C/EBPα) is an essential transcription factor for myeloid lineage commitment. Here we demonstrate that acetylation of C/EBPα at lysine residues K298 and K302, mediated at least in part by general control non-derepressible 5 (GCN5), impairs C/EBPα DNA-binding abil...

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Detalles Bibliográficos
Autores principales: Bararia, Deepak, Kwok, Hui Si, Welner, Robert S., Numata, Akihiko, Sárosi, Menyhárt B., Yang, Henry, Wee, Sheena, Tschuri, Sebastian, Ray, Debleena, Weigert, Oliver, Levantini, Elena, Ebralidze, Alexander K., Gunaratne, Jayantha, Tenen, Daniel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814574/
https://www.ncbi.nlm.nih.gov/pubmed/27005833
http://dx.doi.org/10.1038/ncomms10968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814574/
https://www.ncbi.nlm.nih.gov/pubmed/27005833
http://dx.doi.org/10.1038/ncomms10968

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